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3-Pyridinecarboxylicacid, 2-[(3-chloro-2-methylphenyl)amino]- cas no:17737-65-4

Synonyms: Nicotinicacid, 2-(3-chloro-o-toluidino)- (8CI);2-(2-Methyl-3-chloroanilino)nicotinicacid;2-(2'-Methyl-3'-chloro)-anilinonicotinic acid;2-(3-Chloro-2-methylanilino)-3-pyridinecarboxylic acid;2-(3-Chloro-2-methylanilino)nicotinic acid;CBA 93626;Chlonixin;Clonixicacid;Clonixine;NSC 335505;Sch 10304;

Identification
Name3-Pyridinecarboxylicacid, 2-[(3-chloro-2-methylphenyl)amino]-
CAS17737-65-4
SynonymsNicotinicacid, 2-(3-chloro-o-toluidino)- (8CI);2-(2-Methyl-3-chloroanilino)nicotinicacid;2-(2'-Methyl-3'-chloro)-anilinonicotinic acid;2-(3-Chloro-2-methylanilino)-3-pyridinecarboxylic acid;2-(3-Chloro-2-methylanilino)nicotinic acid;CBA 93626;Chlonixin;Clonixicacid;Clonixine;NSC 335505;Sch 10304;
EINECS(EC#)241-730-1
Molecular FormulaC13H11ClN2O2
Molecular Weight262.71
Chemical Properties
refractive index1.665
Safety Data

Safety Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx.

Toxicity

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

mouse

LD50

intraperitoneal

198mg/kg (198mg/kg)

behavioral: convulsions or effect on seizure threshold
behavioral: ataxia
gastrointestinal: ulceration or bleeding from stomach

Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.

mouse

LD50

oral

400mg/kg (400mg/kg)

behavioral: convulsions or effect on seizure threshold
behavioral: ataxia
gastrointestinal: ulceration or bleeding from stomach

Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.

mouse

LD50

subcutaneous

263mg/kg (263mg/kg)

behavioral: convulsions or effect on seizure threshold
behavioral: ataxia
gastrointestinal: ulceration or bleeding from stomach

Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.

rat

LD50

intraperitoneal

148mg/kg (148mg/kg)

behavioral: convulsions or effect on seizure threshold
behavioral: ataxia
gastrointestinal: ulceration or bleeding from stomach

Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.

rat

LD50

oral

335mg/kg (335mg/kg)

behavioral: convulsions or effect on seizure threshold
behavioral: ataxia
gastrointestinal: ulceration or bleeding from stomach

Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.

rat

LD50

subcutaneous

325mg/kg (325mg/kg)

behavioral: convulsions or effect on seizure threshold
behavioral: ataxia
gastrointestinal: ulceration or bleeding from stomach

Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.

 

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