9H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one,10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-,(6aR,11aS,11bR)-rel- cas no:18172-33-3

Name9H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one,10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-,(6aR,11aS,11bR)-rel-
CAS18172-33-3
Synonyms9H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one,10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aa,11ab,11ba)- (8CI); Cyclopiazonic acid; NSC 117181; a-Cyclopiazonic acid
Molecular FormulaC20H20 N2 O3
Molecular Weight336.42

refractive index1.626
storage temp−20°C

Hazardclass6.1(a)

Hazard T: Toxic;
Risk R25
Safety

Poison by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
 

Hazard Codes: T
Risk Statements: 25
R25 :Toxic if swallowed.
Safety Statements: 36/37/39-45
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
 

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	oral	12mg/kg (12mg/kg)		Poultry Science. Vol. 65(Suppl,
mouse	LD50	intraperitoneal	13mg/kg (13mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Food and Chemical Toxicology. Vol. 23, Pg. 831, 1985.
mouse	LD50	oral	64mg/kg (64mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Research Communications in Chemical Pathology and Pharmacology. Vol. 55, Pg. 303, 1987.
rabbit	LDLo	intraperitoneal	10mg/kg (10mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Food and Chemical Toxicology. Vol. 23, Pg. 831, 1985.
rat	LD50	intraperitoneal	2mg/kg (2mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Toxicology and Applied Pharmacology. Vol. 18, Pg. 114, 1971.
rat	LD50	oral	36mg/kg (36mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Toxicology and Applied Pharmacology. Vol. 18, Pg. 114, 1971.

Carcinogenicity of Cyclopiazonic acid (CAS NO.18172-33-3) hasn't been listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65. You can see actual entry in RTECS for complete information.