dog |
LD50 |
intravenous |
670mg/kg (670mg/kg) |
behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory depression gastrointestinal: nausea or vomiting |
Chemotherapy Vol. 17, Pg. 1523, 1969. |
dog |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
gastrointestinal: ulceration or bleeding from stomach gastrointestinal: nausea or vomiting |
Chemotherapy Vol. 17, Pg. 1523, 1969. |
mouse |
LD50 |
intraperitoneal |
1350mg/kg (1350mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 697, 1982. |
mouse |
LD50 |
intravenous |
1360mg/kg (1360mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 697, 1982. |
mouse |
LD50 |
oral |
7600mg/kg (7600mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 697, 1982. |
mouse |
LD50 |
subcutaneous |
1450mg/kg (1450mg/kg) |
behavioral: convulsions or effect on seizure threshold behavioral: muscle weakness |
Chemotherapy Vol. 17, Pg. 1523, 1969. |
rabbit |
LD50 |
intravenous |
710mg/kg (710mg/kg) |
behavioral: somnolence (general depressed activity) lungs, thorax, or respiration: respiratory depression |
Chemotherapy Vol. 17, Pg. 1523, 1969. |
rabbit |
LD50 |
oral |
> 8gm/kg (8000mg/kg) |
autonomic nervous system: "smooth muscle relaxant (mechanism undefined, spasmolytic)" behavioral: somnolence (general depressed activity) |
Chemotherapy Vol. 17, Pg. 1523, 1969. |
rat |
LD50 |
intraperitoneal |
1100mg/kg (1100mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 697, 1982. |
rat |
LD50 |
intravenous |
680mg/kg (680mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 697, 1982. |
rat |
LD50 |
oral |
11gm/kg (11000mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 697, 1982. |
rat |
LD50 |
subcutaneous |
2800mg/kg (2800mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 697, 1982. |
women |
TDLo |
oral |
120mg/kg/3D-I (120mg/kg) |
liver: "jaundice, cholestatic" |
American Journal of Gastroenterology. Vol. 82, Pg. 483, 1987. |
women |
TDLo |
oral |
210mg/kg/7D-I (210mg/kg) |
liver: "hepatitis (hepatocellular necrosis), zonal" liver: "jaundice, cholestatic" skin and appendages (skin): "dermatitis, other: after systemic exposure" |
Australian and New Zealand Journal of Medicine. Vol. 20, Pg. 251, 1990. |