1847-24-1|4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1), (2S,5R,6R)-Products Supply

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1), (2S,5R,6R)- cas no:1847-24-1

Synonyms: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-,sodium salt (7CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, [2S-(2a,5a,6b)]-;Floxacillin sodium;Floxapen;Floxapen sodium;Flucloxacillin sodium salt;Monosodium flucloxacillin;NSC 277175;Sodium[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin;Sodium flucloxacillin;Staphylex;

Identification

Name4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1), (2S,5R,6R)-
CAS1847-24-1
Synonyms4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-,sodium salt (7CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, [2S-(2a,5a,6b)]-;Floxacillin sodium;Floxapen;Floxapen sodium;Flucloxacillin sodium salt;Monosodium flucloxacillin;NSC 277175;Sodium[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin;Sodium flucloxacillin;Staphylex;
EINECS(EC#)217-428-0
Molecular FormulaC₁₉H₁₆ClFN₃NaO₅S
Molecular Weight475.85

Chemical Properties

AppearanceWhite solid

Safety Data

Safety

Moderately toxic by intravenous, intraperitoneal, and subcutaneous routes. Mildly toxic by ingestion. Human systemic effects: cholestatic jaundice. An experimental teratogen. When heated to decomposition it emits toxic fumes of F⁻, Cl⁻, SO_x, NO_x, and Na₂O.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	670mg/kg (670mg/kg)	behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory depression gastrointestinal: nausea or vomiting	Chemotherapy Vol. 17, Pg. 1523, 1969.
dog	LD50	oral	> 10gm/kg (10000mg/kg)	gastrointestinal: ulceration or bleeding from stomach gastrointestinal: nausea or vomiting	Chemotherapy Vol. 17, Pg. 1523, 1969.
mouse	LD50	intraperitoneal	1350mg/kg (1350mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
mouse	LD50	intravenous	1360mg/kg (1360mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
mouse	LD50	oral	7600mg/kg (7600mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
mouse	LD50	subcutaneous	1450mg/kg (1450mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: muscle weakness	Chemotherapy Vol. 17, Pg. 1523, 1969.
rabbit	LD50	intravenous	710mg/kg (710mg/kg)	behavioral: somnolence (general depressed activity) lungs, thorax, or respiration: respiratory depression	Chemotherapy Vol. 17, Pg. 1523, 1969.
rabbit	LD50	oral	> 8gm/kg (8000mg/kg)	autonomic nervous system: "smooth muscle relaxant (mechanism undefined, spasmolytic)" behavioral: somnolence (general depressed activity)	Chemotherapy Vol. 17, Pg. 1523, 1969.
rat	LD50	intraperitoneal	1100mg/kg (1100mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
rat	LD50	intravenous	680mg/kg (680mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
rat	LD50	oral	11gm/kg (11000mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
rat	LD50	subcutaneous	2800mg/kg (2800mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
women	TDLo	oral	120mg/kg/3D-I (120mg/kg)	liver: "jaundice, cholestatic"	American Journal of Gastroenterology. Vol. 82, Pg. 483, 1987.
women	TDLo	oral	210mg/kg/7D-I (210mg/kg)	liver: "hepatitis (hepatocellular necrosis), zonal" liver: "jaundice, cholestatic" skin and appendages (skin): "dermatitis, other: after systemic exposure"	Australian and New Zealand Journal of Medicine. Vol. 20, Pg. 251, 1990.

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4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1), (2S,5R,6R)- cas no:1847-24-1

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