1847-24-1|4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1), (2S,5R,6R)-Products Supply

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1), (2S,5R,6R)- cas no:1847-24-1

Synonyms: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-,sodium salt (7CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, [2S-(2a,5a,6b)]-;Floxacillin sodium;Floxapen;Floxapen sodium;Flucloxacillin sodium salt;Monosodium flucloxacillin;NSC 277175;Sodium[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin;Sodium flucloxacillin;Staphylex;

Identification

Name4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1), (2S,5R,6R)-
CAS1847-24-1
Synonyms4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-,sodium salt (7CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, [2S-(2a,5a,6b)]-;Floxacillin sodium;Floxapen;Floxapen sodium;Flucloxacillin sodium salt;Monosodium flucloxacillin;NSC 277175;Sodium[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin;Sodium flucloxacillin;Staphylex;
EINECS(EC#)217-428-0
Molecular FormulaC₁₉H₁₆ClFN₃NaO₅S
Molecular Weight475.85

Chemical Properties

AppearanceWhite solid

Safety Data

Safety

Moderately toxic by intravenous, intraperitoneal, and subcutaneous routes. Mildly toxic by ingestion. Human systemic effects: cholestatic jaundice. An experimental teratogen. When heated to decomposition it emits toxic fumes of F⁻, Cl⁻, SO_x, NO_x, and Na₂O.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	670mg/kg (670mg/kg)	behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory depression gastrointestinal: nausea or vomiting	Chemotherapy Vol. 17, Pg. 1523, 1969.
dog	LD50	oral	> 10gm/kg (10000mg/kg)	gastrointestinal: ulceration or bleeding from stomach gastrointestinal: nausea or vomiting	Chemotherapy Vol. 17, Pg. 1523, 1969.
mouse	LD50	intraperitoneal	1350mg/kg (1350mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
mouse	LD50	intravenous	1360mg/kg (1360mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
mouse	LD50	oral	7600mg/kg (7600mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
mouse	LD50	subcutaneous	1450mg/kg (1450mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: muscle weakness	Chemotherapy Vol. 17, Pg. 1523, 1969.
rabbit	LD50	intravenous	710mg/kg (710mg/kg)	behavioral: somnolence (general depressed activity) lungs, thorax, or respiration: respiratory depression	Chemotherapy Vol. 17, Pg. 1523, 1969.
rabbit	LD50	oral	> 8gm/kg (8000mg/kg)	autonomic nervous system: "smooth muscle relaxant (mechanism undefined, spasmolytic)" behavioral: somnolence (general depressed activity)	Chemotherapy Vol. 17, Pg. 1523, 1969.
rat	LD50	intraperitoneal	1100mg/kg (1100mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
rat	LD50	intravenous	680mg/kg (680mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
rat	LD50	oral	11gm/kg (11000mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
rat	LD50	subcutaneous	2800mg/kg (2800mg/kg)		Drugs in Japan Vol. 6, Pg. 697, 1982.
women	TDLo	oral	120mg/kg/3D-I (120mg/kg)	liver: "jaundice, cholestatic"	American Journal of Gastroenterology. Vol. 82, Pg. 483, 1987.
women	TDLo	oral	210mg/kg/7D-I (210mg/kg)	liver: "hepatitis (hepatocellular necrosis), zonal" liver: "jaundice, cholestatic" skin and appendages (skin): "dermatitis, other: after systemic exposure"	Australian and New Zealand Journal of Medicine. Vol. 20, Pg. 251, 1990.

supplier list

WUHAN LIPHARMA CHEMICALS CO.,LTD: Tel:+86-27-85551456; Address: Room 1401, Shangheju, 34 Jianghanbeilu, Wuhan, China.

Zhejiang Huadee Dyestuff Chemical CO., LTD.: Tel:+86-576-8882 8079 ,8882 8188; Address: Industrial Development Zone Of Jiaojiang City Jiaojiang,Zhejiang China

surya pharmaceutical ltd: Tel:+91 172 5005000; Address: 1242, sec 18 c , chandigarh

Shandong Bairui Pharmaceutical Co., Ltd.: Tel:+86-530-2213530 2211300 2221068 2110056; Address: Hepinglu, Dingtao county, Shandong, China

Aurobindo Pharma Ltd.: Tel:+91-40- 5572 5000; Address: Plot # 2, Maitri Vihar, Ameerpet,Hyderabad ?500 038,Andhra Pradesh, India

Taizhou Shengyu Dyestuff Chemical Co.,Ltd.: Tel:+86-(576)-88861016, 88861026; Address: Room 1308-1310, Ocean Plaza, Taizhou, Zhejiang 318000,

Changzhou Qihua Chemical Co., Ltd.: Tel:+86-(519)-8331-0780; Address:

Guangzhou Bairui Medicine Co., Ltd.: Tel:+86-(20)-87358016; Address: 2/F,Nan Ya Building A,No.97,South Si You Road, Guangzhou, Guangdong,

Shijiazhuang Tianyue Fine Chemicals Co., Ltd.: Tel:+86-(311)-86597288, 88120366; Address: 8# Dongning Rd, Gaocheng, Hebei,

Zhejiang Taizhou Dyestuff Chemical Industry: Tel:+86-(576)-8881888, 8828079,8828188; Address: Waisha Industrial Development Zone Of Jiaojiang City, Zhejiang 318000,

Parchem - Fine & Specialty Chemicals: Tel:+1-(914)-654-6800, 800-282-3982; Address: 415 Huguenot Street, New Rochelle, New York 10801,

Shreeji Pharma International: Tel:+91-265-3019110; Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018,

Kouting Chemical Co.,Ltd: Tel:+86-(21)-58116473; Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318,

Jinan Haohua Industry Co., Ltd.: Tel:0086-531-58773055; Address: No.59 Gongye South RD

Hangzhou Dayangchem Co., Ltd.: Tel:86-571-88938639; Address: 9/F Unit 2 ChangdiTorch Building, 259 #WenSan Road

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1), (2S,5R,6R)- cas no:1847-24-1

Directory

supplier list