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2-tert-Butyl-4,6-dimethylphenol cas no:1879-09-0

Synonyms: 6-tert-butyl-2,4-xylenol; 2-(tert-Butyl)-4,6-dimethylphenol; Butyldimethylphenol; 6-Tert-Butyl-2,4-Dthyl Phenol; 2,4-Dimethyl-6-tert-butylphenol; Topanol A; Antioxidant AO30; Topanol An Liquid; IONOL K65; IONOL K72; IONOL K98

Identification
Name2-tert-Butyl-4,6-dimethylphenol
CAS1879-09-0
Synonyms6-tert-butyl-2,4-xylenol; 2-(tert-Butyl)-4,6-dimethylphenol; Butyldimethylphenol; 6-Tert-Butyl-2,4-Dthyl Phenol; 2,4-Dimethyl-6-tert-butylphenol; Topanol A; Antioxidant AO30; Topanol An Liquid; IONOL K65; IONOL K72; IONOL K98
EINECS(EC#)217-533-1
Molecular FormulaC12H18O
Molecular Weight178.27
Chemical Properties
AppearanceColorless liquid or White crystal
refractive index1.6186 (20 C)
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard Xn:Harmful;
Risk R20/21/22;R36/37/38
Safety

Poison by skin contact. Moderately toxic by ingestion. When heated to decomposition it emits smoke and acrid, irritating fumes.
Hazard Codes: HarmfulXn
Risk Statements: 20/21/22-36/37/38 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 2927
RTECS: ZE6825000
Hazard Note: Harmful
HazardClass: 6.1(a)
PackingGroup of Topanol A (CAS NO.1879-09-0): I


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo oral 420mg/kg (420mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.
guinea pig LDLo skin 7100mg/kg (7100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.
mouse LD50 oral 530mg/kg (530mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.
rabbit LDLo oral 55mg/kg (55mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.
rabbit LDLo skin 17mg/kg (17mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. OTS0555501,
rat LDLo oral 1400mg/kg (1400mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.

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