Streptozocin cas no:18883-66-4
Synonyms: 2-desoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose; 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-d-glucose; Streptozotocin
NameStreptozocin
CAS18883-66-4
Synonyms2-desoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose; 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-d-glucose; Streptozotocin
EINECS(EC#)242-646-8
Molecular FormulaC8H15N3O7
Molecular Weight265.22
AppearancePale yellow crystalline powder
refractive index1.67
storage temp?20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard T:Toxic
Risk R22;R45;R46;R61
Safety
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Experimental poison by intravenous, parenteral, subcutaneous, and intraperitoneal routes. Moderately toxic to humans by intravenous route. Human systemic effects: nausea or vomiting, impaired liver function, kidney changes. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also?NITROSAMINES.
The Hazard Codes of Streptozoticin (18883-66-4): 
?Xn,?
T
HazardClass: 6.1(b)
The Risk Statements information of Streptozoticin (18883-66-4):
22:? Harmful if swallowed?
40:? Limited evidence of a carcinogenic effect???
45:? May cause cancer?
46:? May cause heritable genetic damage?
61:? May cause harm to the unborn child?
20/21/22:? Harmful by inhalation, in contact with skin and if swallowed?
The Safety Statements information of Streptozoticin (18883-66-4):
22:? Do not breathe dust?
36:? Wear suitable protective clothing?
45:? In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?
53:? Avoid exposure - obtain special instruction before use?
36/37:? Wear suitable protective clothing and gloves?
RIDADR: 3249
WGK Germany: 3
RTECS: LZ5775000
F: 3-10-21
PackingGroup: III
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mmo-sat 20?ng/plate
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TAKHAA ?? Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. 44 (1985),96. |
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dns-rat-ipr 250?mg/kg
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ENMUDM ?? Environmental Mutagenesis. 7 (1985),889. |
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ivn-wmn TDLo:13,513?μg/kg
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NEJMAG ?? New England Journal of Medicine. 311 (1984),798. |
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ivn-wmn LDLo:440?mg/kg/65W-I
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GUTTAK ?? Gut. 12 (1971),717. |
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ivn-hmn TDLo:1044?mg/kg/5D:GIT,LIV,KID
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CANCAR ?? Cancer. 34 (1974),993. |
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ivn-rat LD50:138?mg/kg
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CNCRA6 ?? Cancer Chemotherapy Reports. 29 (1963),91. |
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ipr-mus LD50:360?mg/kg
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JMCMAR ?? Journal of Medicinal Chemistry. 19 (1976),918. |
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scu-mus LD50:335?mg/kg
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NCISP* ?? National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 . |
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ivn-mus LD50:275?mg/kg
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JMCMAR ?? Journal of Medicinal Chemistry. 19 (1976),918. |
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par-mus LD50:264?mg/kg
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CNCRA6 ?? Cancer Chemotherapy Reports. 48 (1965),1. |
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&n |
?Streptozoticin (18883-66-4) has been listed as a carcinogen NTP, IARC. Streptozocin - California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2B carcinogen. Mutagenicity: Ames-test: positive. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.
