19237-84-4|prazosin hydrochlorideProducts Supply - Chemical intermediates Network

prazosin hydrochloride cas no:19237-84-4

Synonyms: Prazosin HCl

Identification

Nameprazosin hydrochloride
CAS19237-84-4
SynonymsPrazosin HCl
EINECS(EC#)242-903-4
Molecular FormulaC19H21N5O4?HCl;C19H22ClN5
Molecular Weight383.40114

Chemical Properties

Appearanceoff-white to yellow powder

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn:Harmful
Risk R22;R36/37/38;R62
Safety

Safety Information of Prazosin hydrochloride (CAS NO.19237-84-4):
Hazard Codes: Xn
Risk Statements: 22-36/37/38-62?
22:? Harmful if swallowed?
36:? Irritating to the eyes?
37:? Irritating to the respiratory system?
38:? Irritating to the skin?
?Possible risk of impaired fertility
Safety Statements: 28-36
28:? After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)?
36:? Wear suitable protective clothing??

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 700mg/kg (700mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
human	TDLo	oral	285ug/kg (0.285mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	JAMA, Journal of the American Medical Association. Vol. 238, Pg. 157, 1977.
man	TDLo	oral	1714ug/kg (1.714mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Human Toxicology. Vol. 4, Pg. 53, 1985
mouse	LD50	intraperitoneal	60mg/kg (60mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
mouse	LD50	intravenous	92mg/kg (92mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	New Cardiovascular Drugs. Vol. 4, Pg. 1, 1986.
mouse	LD50	oral	5gm/kg (5000mg/kg)	?	Medicamentos de Actualidad. Vol. 11, Pg. 64, 1975.
mouse	LD50	subcutaneous	3100mg/kg (3100mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
rat	LD50	intraperitoneal	102mg/kg (102mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
rat	LD50	intravenous	73mg/kg (73mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	New Cardiovascular Drugs. Vol. 4, Pg. 1, 1986.
rat	LD50	oral	1950mg/kg (1950mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
rat	LD50	subcutaneous	3750mg/kg (3750mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.
women	TDLo	oral	10ug/kg (0.01mg/kg)	BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 723, 1987.
women	TDLo	oral	13mg/kg/6W-I (13mg/kg)	BRAIN AND COVERINGS: ENCEPHALITIS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TOXIC PSYCHOSIS	British Medical Journal. Vol. 293, Pg. 1347, 1986.

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prazosin hydrochloride cas no:19237-84-4

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