| dog |
LD50 |
oral |
> 700mg/kg (700mg/kg) |
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979. |
| human |
TDLo |
oral |
285ug/kg (0.285mg/kg) |
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
JAMA, Journal of the American Medical Association. Vol. 238, Pg. 157, 1977. |
| man |
TDLo |
oral |
1714ug/kg (1.714mg/kg) |
BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Human Toxicology. Vol. 4, Pg. 53, 1985 |
| mouse |
LD50 |
intraperitoneal |
60mg/kg (60mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: ATAXIA |
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979. |
| mouse |
LD50 |
intravenous |
92mg/kg (92mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: ATAXIA |
New Cardiovascular Drugs. Vol. 4, Pg. 1, 1986. |
| mouse |
LD50 |
oral |
5gm/kg (5000mg/kg) |
? |
Medicamentos de Actualidad. Vol. 11, Pg. 64, 1975. |
| mouse |
LD50 |
subcutaneous |
3100mg/kg (3100mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: ATAXIA |
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979. |
| rat |
LD50 |
intraperitoneal |
102mg/kg (102mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979. |
| rat |
LD50 |
intravenous |
73mg/kg (73mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
New Cardiovascular Drugs. Vol. 4, Pg. 1, 1986. |
| rat |
LD50 |
oral |
1950mg/kg (1950mg/kg) |
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979. |
| rat |
LD50 |
subcutaneous |
3750mg/kg (3750mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979. |
| women |
TDLo |
oral |
10ug/kg (0.01mg/kg) |
BEHAVIORAL: COMA
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
SKIN AND APPENDAGES (SKIN): SWEATING: OTHER |
Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 723, 1987. |
| women |
TDLo |
oral |
13mg/kg/6W-I (13mg/kg) |
BRAIN AND COVERINGS: ENCEPHALITIS
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TOXIC PSYCHOSIS |
British Medical Journal. Vol. 293, Pg. 1347, 1986. |
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