OXOLAMINE CITRATE cas no:1949-20-8
Synonyms: OXOLAMINE CITRATE;OXOLAMINE CITRATE SALT;2,4-oxadiazole,5-(2-(diethylamino)ethyl)-3-phenyl-citrate;3-phenyl-5-(beta-(diethylamino)ethyl)-1,2,4-oxadiazolecitrate;5-beta-diethylaminoethyl-3-phenyl-1,2,4-oxadiazolecitrate;5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE;5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT;oxolamine dihydrogen citrate
NameOXOLAMINE CITRATE
CAS1949-20-8
SynonymsOXOLAMINE CITRATE;OXOLAMINE CITRATE SALT;2,4-oxadiazole,5-(2-(diethylamino)ethyl)-3-phenyl-citrate;3-phenyl-5-(beta-(diethylamino)ethyl)-1,2,4-oxadiazolecitrate;5-beta-diethylaminoethyl-3-phenyl-1,2,4-oxadiazolecitrate;5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE;5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT;oxolamine dihydrogen citrate
EINECS(EC#)217-760-6
Molecular FormulaC14H19N3O•C6H8O7
Molecular Weight437.50
Appearancewhite or off-white crystalline powder
storage temp2-8°C
Hazard Xn: Harmful;
Risk R22
Safety Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx. See also AMINES and OXOLAMINE; OXOLAMINE HYDROCHLORIDE.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RO0720000
- CHEMICAL NAME :
- 1,2,4-Oxadiazole,
5-(2-(diethylamino)ethyl)-3-phenyl-, citrate
- CAS REGISTRY NUMBER :
- 1949-20-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C14-H19-N3-O.C6-H8-O7
- MOLECULAR WEIGHT :
- 437.50
- WISWESSER LINE NOTATION :
- T5NO DNJ C2N2&2 ER &QV1XQVQ1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1650 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 16,209,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 351 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark
Office, Foreign Patents, Washington, DC 20231) Discontinued.
Volume(issue)/page/year: #683M
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 19,631,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 351 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 16,209,1961
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 43400 mg/kg/7W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in kidney weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- EMPSAL Experimental and Molecular Pathology, Supplement. (New York, NY)
No.1-3, 1963-66. Discontinued. Volume(issue)/page/year: 2,1,1963
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 7177 mg/kg/7W-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands
Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- EMPSAL Experimental and Molecular Pathology, Supplement. (New York, NY)
No.1-3, 1963-66. Discontinued. Volume(issue)/page/year: 2,1,1963
** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 gm/kg/1Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
- REFERENCE :
- EMPSAL Experimental and Molecular Pathology, Supplement. (New York, NY)
No.1-3, 1963-66. Discontinued. Volume(issue)/page/year: 2,1,1963
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 120 mg/kg
- SEX/DURATION :
- female 9-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 17,781,1967
