1951-25-3|Methanone,(2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-Products Supply

Methanone,(2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]- cas no:1951-25-3

Synonyms: Ketone,2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl (7CI,8CI);2-Butyl-3-[3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl]benzofuran;2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone;2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran;Amidorone;Ancaron;Sedacoron;Sedacorone;

Identification

NameMethanone,(2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-
CAS1951-25-3
SynonymsKetone,2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl (7CI,8CI);2-Butyl-3-[3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl]benzofuran;2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone;2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran;Amidorone;Ancaron;Sedacoron;Sedacorone;
EINECS(EC#)217-772-1
Molecular FormulaC₂₅H₂₉I₂NO₃
Molecular Weight645.3116

Chemical Properties

storage temp2-8°C

Safety Data

Hazard Xn:Harmful;
Risk R20/21/22
Safety

Poison by intravenous and intraperitoneal routes. Human systemic effects by ingestion: photosensitivity of the skin. A flammable liquid. When heated to decomposition it emits very toxic fumes of I⁻ and NO_x. A coronary vasodilator.
Hazard Codes: Harmful Xn
Risk Statements: 20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: OB1361000

Toxicity

child	LDLo	oral	568mg/kg/9W-I (568mg/kg)	CARDIAC: PULSE RATE LIVER: FATTY LIVER DEGERATION	Journal of Pediatrics. Vol. 107, Pg. 967, 1985.
man	LDLo	oral	1869mg/kg/22W (1869mg/kg)	BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION ENDOCRINE: EVIDENCE OF THYROID HYPOFUNCTION	American Journal of Medicine. Vol. 77, Pg. 751, 1984.
man	LDLo	oral	2086mg/kg/2Y- (2086mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: LIVER FUNCTION TESTS IMPAIRED	Netherlands Journal of Medicine. Vol. 29, Pg. 303, 1986.
man	LDLo	unreported	3650mg/kg/3.5 (3650mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: OTHER CHANGES ENDOCRINE: OTHER CHANGES	Clinical Endocrinology Vol. 45, Pg. 365, 1996.
man	TDLo	intravenous	4286ug/kg (4.286mg/kg)	BRAIN AND COVERINGS: INCREASED INTRACRANIAL PRESSURE	Critical Care Medicine. Vol. 13, Pg. 688, 1985.
man	TDLo	intravenous	26mg/kg/1D-C (26mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	American Heart Journal. Vol. 131, Pg. 1214, 1996.
man	TDLo	oral	60mg/kg/2W-I (60mg/kg)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: CHANGES IN OTHER CELL COUNT (UNSPECIFIED)	Chest. Vol. 88, Pg. 630, 1985.
man	TDLo	oral	133mg/kg/23D- (133mg/kg)	SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE	Lancet. Vol. 1, Pg. 51, 1984.
man	TDLo	oral	390mg/kg/39W- (390mg/kg)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION	Netherlands Journal of Medicine. Vol. 42, Pg. 21, 1993.
man	TDLo	oral	1714mg/kg/21W (1714mg/kg)	LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: CYANOSIS	New England Journal of Medicine. Vol. 308, Pg. 779, 1983.
man	TDLo	oral	3651mg/kg/2.3 (3651mg/kg)	LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" LIVER: LIVER FUNCTION TESTS IMPAIRED LIVER: MULTIPLE EFFECTS	American Journal of Gastroenterology. Vol. 83, Pg. 161, 1988.
man	TDLo	unreported	51mg/kg/6D-C (51mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	British Medical Journal. Vol. 296, Pg. 1322, 1988.
man	TDLo	unreported	57mg/kg/5D-I (57mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Annals of Internal Medicine. Vol. 97, Pg. 561, 1982.
mouse	LD50	intraperitoneal	254mg/kg (254mg/kg)		European Journal of Toxicology and Environmental Hygiene. Vol. 8, Pg. 122, 1975.
mouse	LD50	intravenous	178mg/kg (178mg/kg)		European Journal of Toxicology and Environmental Hygiene. Vol. 8, Pg. 188, 1975.
mouse	LD50	oral	> 4gm/kg (4000mg/kg)		European Patent Application. Vol. #0076973,
rat	LD50	intraperitoneal	885mg/kg (885mg/kg)		European Patent Application. Vol. #0076973,
women	TDLo	intravenous	3mg/kg (3mg/kg)	BRAIN AND COVERINGS: INCREASED INTRACRANIAL PRESSURE	Critical Care Medicine. Vol. 13, Pg. 688, 1985.
women	TDLo	intravenous	36mg/kg/1D-I (36mg/kg)	ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION	Israel Journal of Medical Sciences. Vol. 21, Pg. 165, 1985.
women	TDLo	multiple routes	1475mg/kg/7W- (1475mg/kg)	CARDIAC: OTHER CHANGES	American Journal of Cardiology. Vol. 58, Pg. 1110, 1986.
women	TDLo	oral	64mg/kg/4D-I (64mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS	Lancet. Vol. 350, Pg. 1300, 1997.
women	TDLo	oral	416mg/kg/30D- (416mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives of Internal Medicine. Vol. 147, Pg. 50, 1987.
women	TDLo	oral	5200mg/kg/5Y- (5200mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Respiration. Vol. 49, Pg. 157, 1986.
women	TDLo	oral	5796mg/kg/69W (5796mg/kg)	ENDOCRINE: OTHER CHANGES MUSCULOSKELETAL: OTHER CHANGES	Italian Journal of Neurological Sciences. Vol. 8, Pg. 605, 1987.
women	TDLo	unreported	48mg/kg/3D-I (48mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	American Heart Journal. Vol. 130, Pg. 399, 1995.

supplier list

Watson International Ltd.: Tel:+86-(512)-55117610; Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332,

Shanghai Xunxin Chemical Co., Ltd: Tel:+86-(21)-38218795; Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315,

Hangzhou Sage Chemical Co., Ltd.: Tel:86-571-86818502; Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road

AOKChem Co., Ltd.: Tel:+86-(21)-50791030 / 68712331; Address: Room 203, Block D, No.333 Cailun Road, Zhangjiang High-tech Park, Shanghai 201203,

Conier Chem & Pharma Co.,Ltd.: Tel:+86-(23)-62922305; Address: 24 South Section 1, Yihuan Road, Chengdu, Sichuan 610065,

Trust & We Co., Ltd.: Tel:86-21-61551611; Address: 601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong, Shanghai, China.

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Chemner Pharma: Tel:+86-(23)-62482345; Address: 668# International Exhibtion and Conference Center, Chongqing, Sichuan 400060,

Baxter International Inc.: Tel:+1-(847)-948-2000; Address: One Baxter Parkway, Deerfield, Illinois 60015-4625,

Laiwu Hehui Chemical Co.,Ltd.: Tel:+86-(531)-88772589; Address: Huashan Rd., Jinan City, Shandong 250000,

Wuhan Haizheng Industry & Trade Development Co. Ltd: Tel:86-27-88660577; Address: 27th FL.shuian international masion Bldg.1,Heping Ave.wuhan city

Boc Sciences: Tel:1-631-5046093; Address: 45-16 Ramsey Road Shirley, NY 11967, USA

Jinan Haohua Industry Co., Ltd.: Tel:0086-531-58773055; Address: No.59 Gongye South RD

Zhejiang Chemline International Co.,Ltd.: Tel:+86-571-88062298; Address: Rm.1101,Eastcom Building,NO.398 Wensan Road,Hangzhou, China.

Methanone,(2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]- cas no:1951-25-3

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