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Tiopronin cas no:1953-02-2

Synonyms: Glycine,N-(2-mercaptopropionyl)- (7CI,8CI);(2-Mercaptopropionyl)glycine;Acadione;CCRIS 1935;Captimer;Epatiol;MPG;MPG(hepatoprotective);N-(2-Mercaptopropionyl)glycine;Sutilan Cusi;Thiolpropionamidoacetic acid;Thiosol;Tioglis;a-Mercaptopropionyglycine;

Identification
NameTiopronin
CAS1953-02-2
SynonymsGlycine,N-(2-mercaptopropionyl)- (7CI,8CI);(2-Mercaptopropionyl)glycine;Acadione;CCRIS 1935;Captimer;Epatiol;MPG;MPG(hepatoprotective);N-(2-Mercaptopropionyl)glycine;Sutilan Cusi;Thiolpropionamidoacetic acid;Thiosol;Tioglis;a-Mercaptopropionyglycine;
EINECS(EC#)217-778-4
Molecular FormulaC5H9NO3S
Molecular Weight163.19
Chemical Properties
AppearanceWhite crystalline powder
refractive index1.518
Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Safety Information about?Meprin (CAS NO.1953-02-2):
Hazard Codes:?HarmfulXn
Risk Statements: 22?
R22: Harmful if swallowed.
Safety Statements: 36/37?
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS: MC0596500
Moderately toxic by ingestion, intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also MERCAPTANS.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 2100mg/kg (2100mg/kg) ? Indian Journal of Experimental Biology. Vol. 19, Pg. 396, 1981.
mouse LD50 intraperitoneal 673mg/kg (673mg/kg) ? Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1138, 1969.
mouse LD50 intravenous 1733mg/kg (1733mg/kg) ? Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985.
mouse LD50 oral 2330mg/kg (2330mg/kg) ? Drugs in Japan Vol. 6, Pg. 456, 1982.
mouse LD50 subcutaneous 2290mg/kg (2290mg/kg) ? Japanese Journal of Antibiotics. Vol. 41, Pg. 105, 1988.
rabbit LD50 intravenous 1800mg/kg (1800mg/kg) BEHAVIORAL: EXCITEMENT "Proceedings of the International Symposium on Thiola, Tokyo, Japan, 1970," Osaka, Japan, Santen Pharmaceutical Co., Ltd., 1970Vol. -, Pg. 9, 1970.
rat LD50 intramuscular 1630mg/kg (1630mg/kg) ? United States Patent Document. Vol. #4242354,
rat LD50 intraperitoneal 1400mg/kg (1400mg/kg) ? Farmaco, Edizione Scientifica. Vol. 41, Pg. 758, 1986.
rat LD50 oral 1300mg/kg (1300mg/kg) ? Drugs in Japan Vol. 6, Pg. 456, 1982.
women TDLo oral 3120mg/kg/26W (3120mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" American Journal of Kidney Diseases. Vol. 19, Pg. 179, 1992.

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