1953-02-2|TioproninProducts Supply - Chemical intermediates Network

Tiopronin cas no:1953-02-2

Synonyms: Glycine,N-(2-mercaptopropionyl)- (7CI,8CI);(2-Mercaptopropionyl)glycine;Acadione;CCRIS 1935;Captimer;Epatiol;MPG;MPG(hepatoprotective);N-(2-Mercaptopropionyl)glycine;Sutilan Cusi;Thiolpropionamidoacetic acid;Thiosol;Tioglis;a-Mercaptopropionyglycine;

Identification

NameTiopronin
CAS1953-02-2
SynonymsGlycine,N-(2-mercaptopropionyl)- (7CI,8CI);(2-Mercaptopropionyl)glycine;Acadione;CCRIS 1935;Captimer;Epatiol;MPG;MPG(hepatoprotective);N-(2-Mercaptopropionyl)glycine;Sutilan Cusi;Thiolpropionamidoacetic acid;Thiosol;Tioglis;a-Mercaptopropionyglycine;
EINECS(EC#)217-778-4
Molecular FormulaC₅H₉NO₃S
Molecular Weight163.19

Chemical Properties

AppearanceWhite crystalline powder
refractive index1.518

Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Safety Information about?Meprin (CAS NO.1953-02-2):
Hazard Codes:? Harmful Xn
Risk Statements: 22?
R22: Harmful if swallowed.
Safety Statements: 36/37?
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS: MC0596500
Moderately toxic by ingestion, intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SO_x and NO_x. See also MERCAPTANS.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	2100mg/kg (2100mg/kg)	?	Indian Journal of Experimental Biology. Vol. 19, Pg. 396, 1981.
mouse	LD50	intraperitoneal	673mg/kg (673mg/kg)	?	Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1138, 1969.
mouse	LD50	intravenous	1733mg/kg (1733mg/kg)	?	Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985.
mouse	LD50	oral	2330mg/kg (2330mg/kg)	?	Drugs in Japan Vol. 6, Pg. 456, 1982.
mouse	LD50	subcutaneous	2290mg/kg (2290mg/kg)	?	Japanese Journal of Antibiotics. Vol. 41, Pg. 105, 1988.
rabbit	LD50	intravenous	1800mg/kg (1800mg/kg)	BEHAVIORAL: EXCITEMENT	"Proceedings of the International Symposium on Thiola, Tokyo, Japan, 1970," Osaka, Japan, Santen Pharmaceutical Co., Ltd., 1970Vol. -, Pg. 9, 1970.
rat	LD50	intramuscular	1630mg/kg (1630mg/kg)	?	United States Patent Document. Vol. #4242354,
rat	LD50	intraperitoneal	1400mg/kg (1400mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 41, Pg. 758, 1986.
rat	LD50	oral	1300mg/kg (1300mg/kg)	?	Drugs in Japan Vol. 6, Pg. 456, 1982.
women	TDLo	oral	3120mg/kg/26W (3120mg/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	American Journal of Kidney Diseases. Vol. 19, Pg. 179, 1992.

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Tiopronin cas no:1953-02-2

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