1977-10-2|Dibenz[b,f][1,4]oxazepine,2-chloro-11-(4-methyl-1-piperazinyl)-Products Supply

Dibenz[b,f][1,4]oxazepine,2-chloro-11-(4-methyl-1-piperazinyl)- cas no:1977-10-2

Synonyms: 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine;2-Chloro-11-(4-methylpiperazino)dibenz[b,f][1,4]oxazepine; CL 62362;Cloxazepine; HF 3170; LW 3170; Loxapin; Loxapine; Loxitane IM; Oxilapine; S805; SUM 3170

Identification

NameDibenz[b,f][1,4]oxazepine,2-chloro-11-(4-methyl-1-piperazinyl)-
CAS1977-10-2
Synonyms2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine;2-Chloro-11-(4-methylpiperazino)dibenz[b,f][1,4]oxazepine; CL 62362;Cloxazepine; HF 3170; LW 3170; Loxapin; Loxapine; Loxitane IM; Oxilapine; S805; SUM 3170
EINECS(EC#)217-835-3
Molecular FormulaC18H18 Cl N3 O
Molecular Weight327.84

Safety Data

Safety

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Experimental teratogenic and reproductive effects. A tranquilizer. Many dibenz-azepine compounds have central nervous system effects. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD	subcutaneous	> 50mg/kg (50mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 131, 1970.
dog	LD	subcutaneous	> 50mg/kg (50mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 131, 1970.
guinea pig	LDLo	subcutaneous	100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: REGIDITY BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 131, 1970.
mouse	LD50	intraperitoneal	27mg/kg (27mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 79, 1972.
mouse	LD50	intravenous	22mg/kg (22mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 293, 1970.
mouse	LD50	oral	40mg/kg (40mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 79, 1972.
mouse	LD50	subcutaneous	53mg/kg (53mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 293, 1970.
rabbit	LDLo	subcutaneous	50mg/kg (50mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 131, 1970.
rat	LD50	intraperitoneal	35mg/kg (35mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 293, 1970.
rat	LD50	intravenous	18mg/kg (18mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 293, 1970.
rat	LD50	oral	151mg/kg (151mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 293, 1970.
rat	LD50	subcutaneous	350mg/kg (350mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 293, 1970.

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Beijing HuameiHuli Biochem Ltd: Tel:010-86181995; Address: Beijing TongZhou District

Dibenz[b,f][1,4]oxazepine,2-chloro-11-(4-methyl-1-piperazinyl)- cas no:1977-10-2

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