LYSENYL HYDROGEN MALEATE cas no:19875-60-6

NameLYSENYL HYDROGEN MALEATE
CAS19875-60-6
Synonyms1-((5r,8s)-6-methyl-9,10-didehydro-8-ergolinyl)-3,3-diethylureahydrogenmale;3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylureamaleate(1:1);3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-uremaleate(1:1);3-(9,10-didehydro-6-methylergolin-8-yl)-1,1-diethylureahydrogenmaleate;cuvalit;lisuridehydrogenmaleate;lisuridemaleate;lysenyl
EINECS(EC#)243-387-3
Molecular FormulaC₂₀H₂₆N₄O•C₄H₄O₄
Molecular Weight454.58

Safety

The safety information of Lisuride Maleate (CAS NO.19875-60-6):
Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects by ingestion: headache, nausea or vomiting, cardiac changes, sweating. Experimental reproductive effects. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.

The toxicity of Lisuride Maleate (CAS NO.19875-60-6):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	714ng/kg (0.000714mg/kg)	BEHAVIORAL: HEADACHE GASTROINTESTINAL: NAUSEA OR VOMITING	Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 220, 1966.
man	TDLo	intravenous	1429ng/kg/3M- (0.001429mg/kg)	CARDIAC: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Chest. Vol. 91, Pg. 792, 1987.
mouse	LD50	intravenous	14800ug/kg (14.8mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 1165, 1981.
mouse	LD50	oral	90mg/kg (90mg/kg)		United States Patent Document. Vol. #3681497,
mouse	LD50	subcutaneous	82mg/kg (82mg/kg)		United States Patent Document. Vol. #3681497,
rabbit	LD50	oral	123mg/kg (123mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 1165, 1981.
rat	LD50	intravenous	1500ug/kg (1.5mg/kg)		United States Patent Document. Vol. #3681497,
rat	LD50	oral	12500ug/kg (12.5mg/kg)		United States Patent Document. Vol. #3681497,
rat	LD50	subcutaneous	3mg/kg (3mg/kg)		United States Patent Document. Vol. #3681497,