2062-78-4|2H-Benzimidazol-2-one,1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-Products Supply

2H-Benzimidazol-2-one,1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro- cas no:2062-78-4

Synonyms: 2-Benzimidazolinone,1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]- (7CI,8CI);1-(1-(4,4-Bis(4-fluorophenyl)butyl)-4-piperindinyl)-1,3-dihydro-2H-benzimidazol-2-one;1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone;1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine; NSC170984; Orap; Pimozide; Primozide; R 6238

Identification

Name2H-Benzimidazol-2-one,1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-
CAS2062-78-4
Synonyms2-Benzimidazolinone,1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]- (7CI,8CI);1-(1-(4,4-Bis(4-fluorophenyl)butyl)-4-piperindinyl)-1,3-dihydro-2H-benzimidazol-2-one;1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone;1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine; NSC170984; Orap; Pimozide; Primozide; R 6238
EINECS(EC#)218-171-7
Molecular FormulaC28H29 F2 N3 O
Molecular Weight461.60

Chemical Properties

refractive index1.596
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn: Harmful;
Risk R22
Safety

Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and F⁻.
Hazard Codes Harmful Xn
Risk Statements 22
R22:Harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
RIDADR 3249
WGK Germany 3
RTECS DE1750000
HazardClass 6.1(b)
PackingGroup III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	32mg/kg (32mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
dog	LD50	oral	40mg/kg (40mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
guinea pig	LD50	oral	189mg/kg (189mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
man	TDLo	oral	7714ug/kg/15W (7.714mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FLUID INTAKE KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Journal of Clinical Pyschopharmacology. Vol. 12, Pg. 140, 1992.
mouse	LD50	intraperitoneal	1070mg/kg (1070mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse	LD50	intravenous	14mg/kg (14mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 288, 1972.
mouse	LD50	oral	228mg/kg (228mg/kg)	BEHAVIORAL: ATAXIA	Collection of Czechoslovak Chemical Communications. Vol. 42, Pg. 1179, 1977.
mouse	LD50	subcutaneous	> 16gm/kg (16000mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972.
rabbit	LD50	intravenous	22mg/kg (22mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rabbit	LD50	oral	40mg/kg (40mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat	LD50	intraperitoneal	350mg/kg (350mg/kg)		Drugs in Japan Vol. 6, Pg. 639, 1982.
rat	LD50	intravenous	90mg/kg (90mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat	LD50	oral	1100mg/kg (1100mg/kg)		Drugs in Japan Vol. 6, Pg. 639, 1982.
rat	LD50	subcutaneous	> 11gm/kg (11000mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972.

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2H-Benzimidazol-2-one,1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro- cas no:2062-78-4

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