20830-81-3|5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)-Products Supply

5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)- cas no:20830-81-3

Synonyms: (+)-Daunomycin;AI3-52942;Acetyladriamycin;BRN 1445583;CCRIS 914;Daunarubicinum;Daunamycin;Cerubidin;DaunoXome;Daunomycin;Daunorrubicina;UNII-ZS7284E0ZP;

Identification

Name5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)-
CAS20830-81-3
Synonyms(+)-Daunomycin;AI3-52942;Acetyladriamycin;BRN 1445583;CCRIS 914;Daunarubicinum;Daunamycin;Cerubidin;DaunoXome;Daunomycin;Daunorrubicina;UNII-ZS7284E0ZP;
EINECS(EC#)244-069-7
Molecular FormulaC₂₇H₂₉NO₁₀
Molecular Weight527.52

Chemical Properties

AppearanceOrange-red powder.
storage tempProtect from light in tightly sealed container.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard A carcinogen (OSHA).
Risk R3249
Safety

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Human poison by ingestion. Experimental poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also DAUNOMYCIN HYDROCHLORIDE.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	10mg/kg/30D-I (10mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION	British Journal of Clinical Practice. Vol. 44, Pg. 633, 1990.
dog	LD50	intravenous	4mg/kg (4mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 948, 1967.
guinea pig	LD50	intravenous	6mg/kg (6mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 948, 1967.
hamster	LDLo	intravenous	50mg/kg (50mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 15, Pg. 1614, 1973.
human	LDLo	oral	6mg/kg (6mg/kg)	CARDIAC: OTHER CHANGES	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 521, 1969.
mouse	LD50	intraperitoneal	2500ug/kg (2.5mg/kg)	GASTROINTESTINAL: OTHER CHANGES	National Cancer Institute Report. Vol. -, Pg. 304, 1967.
mouse	LD50	intravenous	8600ug/kg (8.6mg/kg)		Cancer Research. Vol. 49, Pg. 4098, 1989.
mouse	LD50	oral	205mg/kg (205mg/kg)		Yakkyoku. Pharmacy. Vol. 25, Pg. 573, 1974.
mouse	LD50	unreported	24900ug/kg (24.9mg/kg)		Biochemical Pharmacology. Vol. 38, Pg. 167, 1989.
rabbit	LD50	intravenous	5mg/kg (5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 948, 1967.
rat	LD50	intraperitoneal	20mg/kg (20mg/kg)		Advances in Teratology. Vol. 3, Pg. 181, 1968.
rat	LD50	intravenous	13mg/kg (13mg/kg)	BLOOD: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER	National Cancer Institute Report. Vol. -, Pg. 304, 1967.
rat	LD50	oral	336mg/kg (336mg/kg)		Yakkyoku. Pharmacy. Vol. 25, Pg. 573, 1974.
rat	LD50	subcutaneous	33200ug/kg (33.2mg/kg)		Yakkyoku. Pharmacy. Vol. 25, Pg. 573, 1974.

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Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

SINOCHEM NINGBO LTD.: Tel:86-574-87260209 87348868; Address: 21 Jiangxia St.,Ningbo 315000 .Zhejiang. China

Andard-Mount Company Limited: Tel:020-8991-5150; Address: 20 HANOVER SQUARE,LONDON,W1S 1JY

Qingdao Chinaoil Co., Ltd: Tel:; Address: 22/F,Golden Light Tower,No.56, Xianggang Zhong Road, Qingdao 266071, China

N-Techem International Co.Ltd.: Tel:; Address: Room 803, B Building, LiYuanShangDu, 39#, 158 Lane, HuanCheng XiLu, Ningbo, Zhejiang, China

Yingxuan Chempharm Co., Ltd.: Tel:+86-(21)-50323911; Address: Rm.1705, No.51, JinZang Rd., Pudong, Shanghai 201206,

China ShengDa Pharmaceutical Company: Tel:+86-(755)-81240788; Address: Shenzhen Tech-Innovatio,The Tenth Road,South, Shenzhen, GuangDong 518058,

Hangzhou Kinsey Bio-tech Co., Ltd: Tel:+86-(571)-85318381; Address: 1207, Taihe International Mansion, No.1 Building 168 Chaohui Road, Hangzhou, Zhejiang,

Kang-Sun Pharmaceutical Limited: Tel:+86-(517)-88842817; Address: Jialv Xiyuan 15-2-602,Xihu District, HangZhou, Zhejiang,

Varda Biotech Pvt. Ltd.: Tel:+91-(22)-6693 5686; Address: #110 & 111 Kartik Complex, New Link Road, Andheri (W), Mumbai, Maharashtra 400 053,

Tecoland Corporation: Tel:+1-(732)-603-9577; Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,

Nanjing Xian Hang Medical Technology Co., Ltd.: Tel:+86-(25)-8426-5383; Address: No. 198, Hongwu Road, Nanjing City International Tower B Building, Seventh Floor, Nanjing, Jiangsu 210001,

Facus Pharmaceutical Co., Ltd.: Tel:+86-(574)-6237-8411; Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800,

Jiangyin South Pole Star Biological Products Co., Ltd.: Tel:+86-(510)-8620-1315; Address: South-East Lu, Gui Shan, Huashi Town, Jiangyin, Jiangsu,

Shenzhen Boda Biopharm Co., Ltd.: Tel:+86-(755)-83673338/83673986; Address: Room1605, Sichuan Bldg., No.2001, Hongli Road, Futian District, Shenzhen, Guangdong 518028,

5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)- cas no:20830-81-3

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