20830-81-3|5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)-Products Supply

5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)- cas no:20830-81-3

Synonyms: (+)-Daunomycin;AI3-52942;Acetyladriamycin;BRN 1445583;CCRIS 914;Daunarubicinum;Daunamycin;Cerubidin;DaunoXome;Daunomycin;Daunorrubicina;UNII-ZS7284E0ZP;

Identification

Name5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)-
CAS20830-81-3
Synonyms(+)-Daunomycin;AI3-52942;Acetyladriamycin;BRN 1445583;CCRIS 914;Daunarubicinum;Daunamycin;Cerubidin;DaunoXome;Daunomycin;Daunorrubicina;UNII-ZS7284E0ZP;
EINECS(EC#)244-069-7
Molecular FormulaC₂₇H₂₉NO₁₀
Molecular Weight527.52

Chemical Properties

AppearanceOrange-red powder.
storage tempProtect from light in tightly sealed container.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard A carcinogen (OSHA).
Risk R3249
Safety

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Human poison by ingestion. Experimental poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also DAUNOMYCIN HYDROCHLORIDE.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	10mg/kg/30D-I (10mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION	British Journal of Clinical Practice. Vol. 44, Pg. 633, 1990.
dog	LD50	intravenous	4mg/kg (4mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 948, 1967.
guinea pig	LD50	intravenous	6mg/kg (6mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 948, 1967.
hamster	LDLo	intravenous	50mg/kg (50mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 15, Pg. 1614, 1973.
human	LDLo	oral	6mg/kg (6mg/kg)	CARDIAC: OTHER CHANGES	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 521, 1969.
mouse	LD50	intraperitoneal	2500ug/kg (2.5mg/kg)	GASTROINTESTINAL: OTHER CHANGES	National Cancer Institute Report. Vol. -, Pg. 304, 1967.
mouse	LD50	intravenous	8600ug/kg (8.6mg/kg)		Cancer Research. Vol. 49, Pg. 4098, 1989.
mouse	LD50	oral	205mg/kg (205mg/kg)		Yakkyoku. Pharmacy. Vol. 25, Pg. 573, 1974.
mouse	LD50	unreported	24900ug/kg (24.9mg/kg)		Biochemical Pharmacology. Vol. 38, Pg. 167, 1989.
rabbit	LD50	intravenous	5mg/kg (5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 948, 1967.
rat	LD50	intraperitoneal	20mg/kg (20mg/kg)		Advances in Teratology. Vol. 3, Pg. 181, 1968.
rat	LD50	intravenous	13mg/kg (13mg/kg)	BLOOD: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER	National Cancer Institute Report. Vol. -, Pg. 304, 1967.
rat	LD50	oral	336mg/kg (336mg/kg)		Yakkyoku. Pharmacy. Vol. 25, Pg. 573, 1974.
rat	LD50	subcutaneous	33200ug/kg (33.2mg/kg)		Yakkyoku. Pharmacy. Vol. 25, Pg. 573, 1974.

supplier list

Yingxuan Chempharm Co., Ltd.: Tel:+86-(21)-50323911; Address: Rm.1705, No.51, JinZang Rd., Pudong, Shanghai 201206,

Varda Biotech Pvt. Ltd.: Tel:+91-(22)-6693 5686; Address: #110 & 111 Kartik Complex, New Link Road, Andheri (W), Mumbai, Maharashtra 400 053,

Tecoland Corporation: Tel:+1-(732)-603-9577; Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,

Nanjing Xian Hang Medical Technology Co., Ltd.: Tel:+86-(25)-8426-5383; Address: No. 198, Hongwu Road, Nanjing City International Tower B Building, Seventh Floor, Nanjing, Jiangsu 210001,

Beijing HuameiHuli Biochem Ltd: Tel:010-86181995; Address: Beijing TongZhou District

Hangzhou UNIWISE International Co.,Ltd.: Tel:+86-571-28819531; Address: E-19F, Dongqiing Building, 52 Qingchun Rd, Hangzhou, China

innocechem-api: Tel:18918206905; Address: shanghai

Shanghai Hope Chem Co., Ltd.: Tel:86-21-61723543; Address: Room508, Building1, No.88 CaiLun Road Zhangjiang H

Wuhan H.X.K Fine Chemicals Co.,LTD: Tel:86-27-59721024; Address: No. 139, hanyang Road, hubei city， Hubei Prov. China 434000

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maxchemco: Tel:86-21-54822160; Address:

VARDA Biotech (P) Ltd.: Tel:+91(22) 6693 5686; Address: #110 & 111, Kartik complex, New Link Road, Andheri (W), Mumbai - 400 053, INDIA.

YiPeng Chemical: Tel:571 85376369; Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China

5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)- cas no:20830-81-3

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