21498-08-8|1H-Imidazole,2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, hydrochloride (1:1)Products Supply

1H-Imidazole,2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, hydrochloride (1:1) cas no:21498-08-8

Synonyms: 1H-Imidazole,2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, monohydrochloride (9CI);2-Imidazoline, 2-[1-(2,6-dichlorophenoxy)ethyl]-, monohydrochloride (8CI); Baq168; Britlofex; Lofetensin; Lofexidine hydrochloride; Loxacor; MDL 14042

Identification

Name1H-Imidazole,2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, hydrochloride (1:1)
CAS21498-08-8
Synonyms1H-Imidazole,2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, monohydrochloride (9CI);2-Imidazoline, 2-[1-(2,6-dichlorophenoxy)ethyl]-, monohydrochloride (8CI); Baq168; Britlofex; Lofetensin; Lofexidine hydrochloride; Loxacor; MDL 14042
Molecular FormulaC11H12 Cl2 N2 O . Cl H
Molecular Weight295.61

Safety Data

Safety

Poison by ingestion and intravenous routes. An experimental teratogen. Experimental reproductive effects. An antihypertensive agent. When heated to decomposition it emits toxic fumes of NO_x and HCl.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	8mg/kg (8mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.
dog	LD50	oral	70mg/kg (70mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.
human	TDLo	oral	270ug/kg/6W-I (0.27mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 976, 1982.
mouse	LD50	intravenous	8mg/kg (8mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.
mouse	LD50	oral	54mg/kg (54mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 966, 1982.
rat	LD50	intravenous	8mg/kg (8mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.
rat	LD50	oral	70mg/kg (70mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.

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1H-Imidazole,2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, hydrochloride (1:1) cas no:21498-08-8

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