21593-23-7|5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, (6R,7R)-Products Supply

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, (6R,7R)- cas no:21593-23-7

Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-, acetate (ester)(8CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, (6R-trans)-;7-[2-(4-Pyridylthio)acetamido]cephalosporanic acid; Cefapirin; Cefaprin;Cephapirin; Cephapirine; Cephaprin

Identification

Name5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, (6R,7R)-
CAS21593-23-7
Synonyms5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-, acetate (ester)(8CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, (6R-trans)-;7-[2-(4-Pyridylthio)acetamido]cephalosporanic acid; Cefapirin; Cefaprin;Cephapirin; Cephapirine; Cephaprin
EINECS(EC#)244-466-5
Molecular FormulaC17H17 N3 O6 S2
Molecular Weight423.49

Chemical Properties

AppearanceBeige Solid
refractive index1.688

Safety Data

Safety

Moderately toxic by intraperitoneal route. Human systemic effects by intravenous route: jaundice. Experimental reproductive effects. When Cephapirin (CAS NO.21593-23-7) is heated to decomposition, it emits very toxic fumes of NO_x and SO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intravenous	514ug/kg/9D-I (0.514mg/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"	Drug Intelligence and Clinical Pharmacy. Vol. 19, Pg. 553, 1985.
mouse	LD50	intraperitoneal	8899mg/kg (8899mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 21, Pg. 279, 1974.
mouse	LD50	intravenous	> 7602mg/kg (7602mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 21, Pg. 279, 1974.
mouse	LD50	oral	26088mg/kg (26088mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: IRRITABILITY BEHAVIORAL: ATAXIA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 21, Pg. 279, 1974.
mouse	LD50	subcutaneous	13556mg/kg (13556mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 21, Pg. 279, 1974.
rat	LD50	intraperitoneal	7850mg/kg (7850mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 21, Pg. 279, 1974.
rat	LD50	intravenous	6048mg/kg (6048mg/kg)	SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 21, Pg. 279, 1974.
rat	LD50	oral	16356mg/kg (16356mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: IRRITABILITY	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 21, Pg. 279, 1974.
rat	LD50	subcutaneous	> 14400mg/kg (14400mg/kg)	BEHAVIORAL: ANTIPSYCHOTIC	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 21, Pg. 279, 1974.

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5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, (6R,7R)- cas no:21593-23-7

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