22059-60-5|Disopyramid phosphateProducts Supply - Chemical intermediates Network

Disopyramid phosphate cas no:22059-60-5

Synonyms: 2-[1-(ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridinium phosphate; Norpace CR

Identification

NameDisopyramid phosphate
CAS22059-60-5
Synonyms2-[1-(ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridinium phosphate; Norpace CR
EINECS(EC#)244-756-1
Molecular FormulaC₂₁H₂₉N₃O^.H₃O₄P;C₂₁H₃₂N₃O₅P
Molecular Weight437.47

Safety Data

Hazard Xn: Harmful;
Risk R22
Safety

Human poison by ingestion. Experimental poison by intravenous and intraperitoneal routes. Moderately toxic experimentally by ingestion and subcutaneous routes. Human systemic effects: arrhythmias, blood clotting factor change, hypoglycemia, liver function tests impaired, pulse rate increase, thrombocytopenia. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and PO_x.
Safety Information Rythmodan (22059-60-5):
Hazard Codes: Xn
Xn: Harmful
Risk Statements: 22
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: UR8440000

Toxicity

1.	ipr-rat TDLo:1820 mg/kg (male 10W pre):TER	JZKEDZ Jitchuken, Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Preclinical Reports. 7 (1981),145.
2.	orl-wmn LDLo:60 mg/kg/10D-I:SYS	NYSJAM New York State Journal of Medicine. 83 (1983),1057.
3.	orl-man TDLo:43 mg/kg/5D-I:SYS	NYSJAM New York State Journal of Medicine. 83 (1983),1057.
4.	orl-wmn TDLo:8 mg/kg/1D-I:LIV,BLD	SMJOAV Southern Medical Journal. 75 (1982),496.
5.	orl-man TDLo:1429 µg/kg:SYS	NNGAAS Nippon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine. 72 (1983),1177.
6.	orl-chd LDLo:30 mg/kg	MJAUAJ Medical Journal of Australia. 2 (1978),335.
7.	orl-man TDLo:45 mg/kg/1W-I	SMJOAV Southern Medical Journal. 76 (1983),1453.
8.	orl-wmn TDLo:20 mg/kg/3D-I:CVS,BLD	AHJOA2 American Heart Journal. 105 (1983),870.
9.	orl-rat LD50:880 mg/kg	YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 9 (Suppl 1)(1981),5.
10.	ipr-rat LD50:255 mg/kg	YACHDS

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Disopyramid phosphate cas no:22059-60-5

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