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Silver,[4-amino-N-(2-pyrimidinyl-kN1)benzenesulfonamidato-kO]- cas no:22199-08-2

Synonyms: Silver,(4-amino-N-2-pyrimidinylbenzenesulfonamidato-NN,O1)-;Sulfanilamide,N1-2-pyrimidinyl-, monosilver(1+) salt (8CI);Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex;Dermazin;Flamazine;Flammazine;Geben;NSC 625324;Silvadene;Silver 2-sulfanilamidopyrimidine;Silverol;Sulfadiazine silver;

Identification
NameSilver,[4-amino-N-(2-pyrimidinyl-kN1)benzenesulfonamidato-kO]-
CAS22199-08-2
SynonymsSilver,(4-amino-N-2-pyrimidinylbenzenesulfonamidato-NN,O1)-;Sulfanilamide,N1-2-pyrimidinyl-, monosilver(1+) salt (8CI);Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex;Dermazin;Flamazine;Flammazine;Geben;NSC 625324;Silvadene;Silver 2-sulfanilamidopyrimidine;Silverol;Sulfadiazine silver;
EINECS(EC#)244-834-5
Molecular FormulaC10H9AgN4O2S
Molecular Weight357.13
Chemical Properties
Appearancesolid
Safety Data

Hazard Xi:Irritant
Risk R36/37/38

Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WP1950000
CHEMICAL NAME :
Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosilver(1+) salt
CAS REGISTRY NUMBER :
22199-08-2
LAST UPDATED :
199712
DATA ITEMS CITED :
34
MOLECULAR FORMULA :
C10-H10-N4-O2-S.Ag
MOLECULAR WEIGHT :
358.17
WISWESSER LINE NOTATION :
T6N CNJ BMSWR DZ &-AG-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
536 mg/kg/21W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
126 mg/kg
TOXIC EFFECTS :
Liver - other changes Blood - changes in spleen Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Liver - other changes Blood - changes in spleen
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Liver - other changes Blood - changes in spleen
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
240 mg/kg/30D-C
TOXIC EFFECTS :
Endocrine - other changes Blood - changes in spleen Biochemical - Effect on specific coenzyme - not otherwise specified
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1456 mg/kg/13W-C
TOXIC EFFECTS :
Liver - other changes Blood - changes in spleen Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
728 mg/kg/26W-C
TOXIC EFFECTS :
Liver - other changes Blood - changes in spleen Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
44 gm/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
11 gm/kg
SEX/DURATION :
male 70 day(s) pre-mating female 2 week(s) pre-mating - 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
11 gm/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
26 gm/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
6500 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Microorganism - not otherwise specified
DOSE/DURATION :
2500 ug/L
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 2,367,1972 *** REVIEWS *** ACGIH TLV-TWA 0.01 mg(Ag)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.01 mg(Ag)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,231,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.01 mg(Ag)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.01 mg(Ag)/m3 JAN 1993 OEL-BELGIUM:TWA 0.01 mg(Ag)/m3 JAN 1993 OEL-DENMARK:TWA 0.01 mg(Ag)/m3 JAN 1993 OEL-FINLAND:TWA 0.01 mg(Ag)/m3;STEL 0.03 mg(Ag)/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.01 mg(Ag)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.01 mg(Ag)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.01 mg(Ag)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.01 mg(Ag)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5603 No. of Facilities: 944 (estimated) No. of Industries: 9 No. of Occupations: 10 No. of Employees: 87352 (estimated) No. of Female Employees: 71312 (estimated)

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