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Naproxene cas no:22204-53-1

Synonyms: (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid; (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid; Naproxen

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Identification
NameNaproxene
CAS22204-53-1
Synonyms(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid; (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid; Naproxen
EINECS(EC#)244-838-7
Molecular FormulaC14H14O3
Molecular Weight230.26
Chemical Properties
Appearancewhite powder
refractive index67.5 ° (C=1, CHCl3)
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Safety Information of?(+)-2-(Methoxy-2-naphthyl)-propionic acid (CAS NO.22204-53-1):
Hazard Codes: Xn?
Risk Statements: 22
22: Harmful if swallowed??
Safety Statements: 36/37
36/37: Wear suitable protective clothing and gloves
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: UF5275000
HazardClass: 6.1(b)
PackingGroup: III
Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous, and intravenous routes. Human systemic effects: acute renal failure, acute tubular necrosis, cholestatic jaundice, dermatitis, diarrhea, excitement, fever, hypermotility, interstitial nephritis, nausea or vomiting. Human teratogenic effects by ingestion: developmental abnormalities of the cardiovascular (circulatory) system, respiratory system, gastrointestinal system, and other developmental abnormalities. Human reproductive effects by ingestion (effects on newborn): change in condition of newborn at birth, biochemical and metabolic effects, and other neonatal measures or effects. Human mutation data reported. An anti-inflammatory, analgesic and antipyretic. An FDA proprietary drug. When heated to decomposition it emits acrid smoke and irritating fumes.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 2250mg/kg/26W (2250mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Journal of Rheumatology. Vol. 26, Pg. 210, 1987.
dog LD50 oral > 1gm/kg (1000mg/kg) ? Yakkyoku. Pharmacy. Vol. 29, Pg. 861, 1978.
dog LD50 unreported 1gm/kg (1000mg/kg) ? Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975.
guinea pig LD50 oral 665mg/kg (665mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
hamster LD50 oral 1400mg/kg (1400mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
hamster LD50 unreported 4110mg/kg (4110mg/kg) ? Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975.
man TDLo oral 54mg/kg (54mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: PROTEINURIS

KIDNEY, URETER, AND BLADDER: HEMATURIA		 Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 173, 1995.
man TDLo oral 114mg/kg/10D- (114mg/kg) BLOOD: CHANGES IN PLATELET COUNT Journal of Clinical Pharmacology. Vol. 40, Pg. 124, 2000.
man TDLo oral 214mg/kg/30D- (214mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION		 Postgraduate Medical Journal. Vol. 56, Pg. 368, 1980.
man TDLo oral 3429mg/kg/35W (3429mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Postgraduate Medical Journal. Vol. 68, Pg. 766, 1992.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg) ? Bollettino Chimico Farmaceutico. Vol. 119, Pg. 600, 1980.
mouse LD50 intravenous 435mg/kg (435mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Journal of Pharmacology and Experimental Therapeutics. Vol. 179, Pg. 114, 1971.
mouse LD50 oral 360mg/kg (360mg/kg) ? Farmaco, Edizione Scientifica. Vol. 40, Pg. 334, 1985.
mouse LD50 subcutaneous 475mg/kg (475mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1039, 1972.
mouse LD50 unreported 1234mg/kg (1234mg/kg) ? Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975.
rat LD50 intraperitoneal 354mg/kg (354mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 829, 1978.
rat LD50 oral 248mg/kg (248mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1265, 1991.
rat LD50 subcutaneous 928mg/kg (928mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1272, 1983.
women LDLo oral 200mg/kg/10D- (200mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 American Journal of Hematology. Vol. 58, Pg. 142, 1998.
women TDLo oral 40mg/kg/2D-I (40mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Scandinavian Journal of Rheumatology. Vol. 15, Pg. 401, 1986.
women TDLo oral 70mg/kg/W-I (70mg/kg) LIVER: "JAUNDICE, CHOLESTATIC" New England Journal of Medicine. Vol. 295, Pg. 1201, 1976.
women TDLo oral 126mg/kg/3W-I (126mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: EOSINOPHILIA		 Japanese Journal of Medicine. Vol. 30, Pg. 32, 1991.
women TDLo oral 315mg/kg/3W-I (315mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 American Journal of Medicine. Vol. 89, Pg. 526, 1990.
women TDLo oral 900mg/kg/9W-I (900mg/kg) SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE Medical Journal of Australia. Vol. 151, Pg. 167, 1989.

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