child |
TDLo |
oral |
2250mg/kg/26W (2250mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
British Journal of Rheumatology. Vol. 26, Pg. 210, 1987. |
dog |
LD50 |
oral |
> 1gm/kg (1000mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 29, Pg. 861, 1978. |
dog |
LD50 |
unreported |
1gm/kg (1000mg/kg) |
? |
Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975. |
guinea pig |
LD50 |
oral |
665mg/kg (665mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
hamster |
LD50 |
oral |
1400mg/kg (1400mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
hamster |
LD50 |
unreported |
4110mg/kg (4110mg/kg) |
? |
Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975. |
man |
TDLo |
oral |
54mg/kg (54mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: PROTEINURIS
KIDNEY, URETER, AND BLADDER: HEMATURIA |
Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 173, 1995. |
man |
TDLo |
oral |
114mg/kg/10D- (114mg/kg) |
BLOOD: CHANGES IN PLATELET COUNT |
Journal of Clinical Pharmacology. Vol. 40, Pg. 124, 2000. |
man |
TDLo |
oral |
214mg/kg/30D- (214mg/kg) |
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
LIVER: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION |
Postgraduate Medical Journal. Vol. 56, Pg. 368, 1980. |
man |
TDLo |
oral |
3429mg/kg/35W (3429mg/kg) |
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
LUNGS, THORAX, OR RESPIRATION: CYANOSIS |
Postgraduate Medical Journal. Vol. 68, Pg. 766, 1992. |
mouse |
LD50 |
intraperitoneal |
500mg/kg (500mg/kg) |
? |
Bollettino Chimico Farmaceutico. Vol. 119, Pg. 600, 1980. |
mouse |
LD50 |
intravenous |
435mg/kg (435mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT |
Journal of Pharmacology and Experimental Therapeutics. Vol. 179, Pg. 114, 1971. |
mouse |
LD50 |
oral |
360mg/kg (360mg/kg) |
? |
Farmaco, Edizione Scientifica. Vol. 40, Pg. 334, 1985. |
mouse |
LD50 |
subcutaneous |
475mg/kg (475mg/kg) |
? |
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1039, 1972. |
mouse |
LD50 |
unreported |
1234mg/kg (1234mg/kg) |
? |
Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975. |
rat |
LD50 |
intraperitoneal |
354mg/kg (354mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 829, 1978. |
rat |
LD50 |
oral |
248mg/kg (248mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1265, 1991. |
rat |
LD50 |
subcutaneous |
928mg/kg (928mg/kg) |
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1272, 1983. |
women |
LDLo |
oral |
200mg/kg/10D- (200mg/kg) |
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
American Journal of Hematology. Vol. 58, Pg. 142, 1998. |
women |
TDLo |
oral |
40mg/kg/2D-I (40mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Scandinavian Journal of Rheumatology. Vol. 15, Pg. 401, 1986. |
women |
TDLo |
oral |
70mg/kg/W-I (70mg/kg) |
LIVER: "JAUNDICE, CHOLESTATIC" |
New England Journal of Medicine. Vol. 295, Pg. 1201, 1976. |
women |
TDLo |
oral |
126mg/kg/3W-I (126mg/kg) |
LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BLOOD: EOSINOPHILIA |
Japanese Journal of Medicine. Vol. 30, Pg. 32, 1991. |
women |
TDLo |
oral |
315mg/kg/3W-I (315mg/kg) |
BEHAVIORAL: EXCITEMENT
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: NAUSEA OR VOMITING |
American Journal of Medicine. Vol. 89, Pg. 526, 1990. |
women |
TDLo |
oral |
900mg/kg/9W-I (900mg/kg) |
SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE |
Medical Journal of Australia. Vol. 151, Pg. 167, 1989. |