22204-53-1|NaproxeneProducts Supply - Chemical intermediates Network

Naproxene cas no:22204-53-1

Synonyms: (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid; (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid; Naproxen

Identification

NameNaproxene
CAS22204-53-1
Synonyms(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid; (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid; Naproxen
EINECS(EC#)244-838-7
Molecular FormulaC14H14O3
Molecular Weight230.26

Chemical Properties

Appearancewhite powder
refractive index67.5 ° (C=1, CHCl3)
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Safety Information of?(+)-2-(Methoxy-2-naphthyl)-propionic acid (CAS NO.22204-53-1):
Hazard Codes: Xn?
Risk Statements: 22
22: Harmful if swallowed??
Safety Statements: 36/37
36/37: Wear suitable protective clothing and gloves
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: UF5275000
HazardClass: 6.1(b)
PackingGroup: III
Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous, and intravenous routes. Human systemic effects: acute renal failure, acute tubular necrosis, cholestatic jaundice, dermatitis, diarrhea, excitement, fever, hypermotility, interstitial nephritis, nausea or vomiting. Human teratogenic effects by ingestion: developmental abnormalities of the cardiovascular (circulatory) system, respiratory system, gastrointestinal system, and other developmental abnormalities. Human reproductive effects by ingestion (effects on newborn): change in condition of newborn at birth, biochemical and metabolic effects, and other neonatal measures or effects. Human mutation data reported. An anti-inflammatory, analgesic and antipyretic. An FDA proprietary drug. When heated to decomposition it emits acrid smoke and irritating fumes.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	2250mg/kg/26W (2250mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	British Journal of Rheumatology. Vol. 26, Pg. 210, 1987.
dog	LD50	oral	> 1gm/kg (1000mg/kg)	?	Yakkyoku. Pharmacy. Vol. 29, Pg. 861, 1978.
dog	LD50	unreported	1gm/kg (1000mg/kg)	?	Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975.
guinea pig	LD50	oral	665mg/kg (665mg/kg)	?	Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
hamster	LD50	oral	1400mg/kg (1400mg/kg)	?	Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
hamster	LD50	unreported	4110mg/kg (4110mg/kg)	?	Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975.
man	TDLo	oral	54mg/kg (54mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: PROTEINURIS KIDNEY, URETER, AND BLADDER: HEMATURIA	Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 173, 1995.
man	TDLo	oral	114mg/kg/10D- (114mg/kg)	BLOOD: CHANGES IN PLATELET COUNT	Journal of Clinical Pharmacology. Vol. 40, Pg. 124, 2000.
man	TDLo	oral	214mg/kg/30D- (214mg/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Postgraduate Medical Journal. Vol. 56, Pg. 368, 1980.
man	TDLo	oral	3429mg/kg/35W (3429mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Postgraduate Medical Journal. Vol. 68, Pg. 766, 1992.
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)	?	Bollettino Chimico Farmaceutico. Vol. 119, Pg. 600, 1980.
mouse	LD50	intravenous	435mg/kg (435mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 179, Pg. 114, 1971.
mouse	LD50	oral	360mg/kg (360mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 40, Pg. 334, 1985.
mouse	LD50	subcutaneous	475mg/kg (475mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1039, 1972.
mouse	LD50	unreported	1234mg/kg (1234mg/kg)	?	Journal of Clinical Pharmacology. Vol. 15, Pg. 311, 1975.
rat	LD50	intraperitoneal	354mg/kg (354mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 829, 1978.
rat	LD50	oral	248mg/kg (248mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 41, Pg. 1265, 1991.
rat	LD50	subcutaneous	928mg/kg (928mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1272, 1983.
women	LDLo	oral	200mg/kg/10D- (200mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	American Journal of Hematology. Vol. 58, Pg. 142, 1998.
women	TDLo	oral	40mg/kg/2D-I (40mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Scandinavian Journal of Rheumatology. Vol. 15, Pg. 401, 1986.
women	TDLo	oral	70mg/kg/W-I (70mg/kg)	LIVER: "JAUNDICE, CHOLESTATIC"	New England Journal of Medicine. Vol. 295, Pg. 1201, 1976.
women	TDLo	oral	126mg/kg/3W-I (126mg/kg)	LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: EOSINOPHILIA	Japanese Journal of Medicine. Vol. 30, Pg. 32, 1991.
women	TDLo	oral	315mg/kg/3W-I (315mg/kg)	BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Medicine. Vol. 89, Pg. 526, 1990.
women	TDLo	oral	900mg/kg/9W-I (900mg/kg)	SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE	Medical Journal of Australia. Vol. 151, Pg. 167, 1989.

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