22254-24-6|Ipratropium bromideProducts Supply - Chemical intermediates Network

Ipratropium bromide cas no:22254-24-6

Synonyms: 8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide,(3-endo,8-syn)- (9CI);8-Isopropylatropinium bromide (6CI,7CI);8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide,(endo,syn)-;Atrovent;N-Isopropylatropinium bromide;N-Isopropylnoratropinium bromomethylate;Sch100;Sch 1000;

Identification

NameIpratropium bromide
CAS22254-24-6
Synonyms8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide,(3-endo,8-syn)- (9CI);8-Isopropylatropinium bromide (6CI,7CI);8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide,(endo,syn)-;Atrovent;N-Isopropylatropinium bromide;N-Isopropylnoratropinium bromomethylate;Sch100;Sch 1000;
EINECS(EC#)244-873-8
Molecular FormulaC₂₀H₃₀NO₃.Br
Molecular Weight412.42

Chemical Properties

Appearancepowder/white solid
storage tempKeep tightly closed.

Safety Data

Hazard Xn
Risk R20/22
Safety

A poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects by inhalation of very small amounts: gastrointestinal changes. An experimental teratogen. Experimental reproductive effects. An eye irritant. Used as a bronchodilator. When heated to decomposition it emits toxic fumes of NO_x and Br⁻. See also BROMIDES.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	1300mg/kg (1300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
dog	LDLo	intravenous	20mg/kg (20mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
mammal (species unspecified)	LD50	intravenous	10mg/kg (10mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Postgraduate Medical Journal, Supplement. Vol. 51(Suppl,
man	TCLo	inhalation	1ug/kg (0.001mg/kg)	GASTROINTESTINAL: OTHER CHANGES	British Medical Journal. Vol. 292, Pg. 380, 1986.
mouse	LD50	intraperitoneal	72mg/kg (72mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 417, 1978.
mouse	LD50	intravenous	12290ug/kg (12.29mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
mouse	LD50	oral	1001mg/kg (1001mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
mouse	LD50	subcutaneous	300mg/kg (300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
rabbit	LD50	oral	1557mg/kg (1557mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 417, 1978.
rat	LD50	intraperitoneal	113mg/kg (113mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: TETANY	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 176, 1979.
rat	LD50	intravenous	15700ug/kg (15.7mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 489, 1979.
rat	LD50	oral	1663mg/kg (1663mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
rat	LD50	subcutaneous	635mg/kg (635mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: TETANY LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 176, 1979.

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Ipratropium bromide cas no:22254-24-6

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