22254-24-6|Ipratropium bromideProducts Supply - Chemical intermediates Network

Ipratropium bromide cas no:22254-24-6

Synonyms: 8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide,(3-endo,8-syn)- (9CI);8-Isopropylatropinium bromide (6CI,7CI);8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide,(endo,syn)-;Atrovent;N-Isopropylatropinium bromide;N-Isopropylnoratropinium bromomethylate;Sch100;Sch 1000;

Identification

NameIpratropium bromide
CAS22254-24-6
Synonyms8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide,(3-endo,8-syn)- (9CI);8-Isopropylatropinium bromide (6CI,7CI);8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide,(endo,syn)-;Atrovent;N-Isopropylatropinium bromide;N-Isopropylnoratropinium bromomethylate;Sch100;Sch 1000;
EINECS(EC#)244-873-8
Molecular FormulaC₂₀H₃₀NO₃.Br
Molecular Weight412.42

Chemical Properties

Appearancepowder/white solid
storage tempKeep tightly closed.

Safety Data

Hazard Xn
Risk R20/22
Safety

A poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects by inhalation of very small amounts: gastrointestinal changes. An experimental teratogen. Experimental reproductive effects. An eye irritant. Used as a bronchodilator. When heated to decomposition it emits toxic fumes of NO_x and Br⁻. See also BROMIDES.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	1300mg/kg (1300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
dog	LDLo	intravenous	20mg/kg (20mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
mammal (species unspecified)	LD50	intravenous	10mg/kg (10mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Postgraduate Medical Journal, Supplement. Vol. 51(Suppl,
man	TCLo	inhalation	1ug/kg (0.001mg/kg)	GASTROINTESTINAL: OTHER CHANGES	British Medical Journal. Vol. 292, Pg. 380, 1986.
mouse	LD50	intraperitoneal	72mg/kg (72mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 417, 1978.
mouse	LD50	intravenous	12290ug/kg (12.29mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
mouse	LD50	oral	1001mg/kg (1001mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
mouse	LD50	subcutaneous	300mg/kg (300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
rabbit	LD50	oral	1557mg/kg (1557mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 417, 1978.
rat	LD50	intraperitoneal	113mg/kg (113mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: TETANY	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 176, 1979.
rat	LD50	intravenous	15700ug/kg (15.7mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 489, 1979.
rat	LD50	oral	1663mg/kg (1663mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 985, 1976.
rat	LD50	subcutaneous	635mg/kg (635mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: TETANY LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 176, 1979.

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Jewim Pharmaceutical (Shandong) Co., Ltd.: Tel:; Address: Taian Hi-Tech Industrial Development Zone,Shandong province,China

Rota Pharm and Chem Co., Ltd.: Tel:; Address: Room 401,Hangzhou Friendship Plaza,No.74 Bbaochu Road, Hangzhou, China

HANGZHOU THINK CHEMICAL CO., LTD.: Tel:; Address: ROOM 719 BUILDING D MEIDU PLAZA 789 MOGANSHAN ROAD HANGZHOU CHINA

Linhai Dongdong Chemical Plant: Tel:+86-(576)-5993408; Address: Yanjiang Chemical Zone, Linhal, Zhejiang 317022,

Tocris Bioscience: Tel:+1-(800)-421-3701; Address: 16144 Westwoods Business Park, Ellisville, Missouri 63021,

Beijing Nordhuns Chemical Technology Co., Ltd.: Tel:+86-(10)-84929330, 86972915; Address: 202 Xinhengji Office Building, No.66 Beiyuan Road, Chaoyang, beijing,

Beijing Merson Pharmaceutical Technology Development Co., Ltd.: Tel:+86-(10)-80484574, 8048344; Address: 2nd Floor , No. 2 Building , No. 14 Houshayu Duan, Jingmi Road, Shunyi, Beijing 101318,

Kouting Chemical Co.,Ltd: Tel:+86-(21)-58116473; Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318,

Bo Jia Science and Technology (Wuhan) Co., Ltd.: Tel:02787526690-8155; Address: Wuhan City, Hubei Province Luo Yu Road, Hongshan No. 424 Technology Innovation Center, 14 Floor, Block A

Beijing Merson Pharmaceutical Co., Ltd: Tel:0086-10-80484934 0086-10-80484574/80483447; Address: 2nd Floor , No. 2 Building , No. 14 Houshayu Duan, Jingmi Road ,Shunyi District , Beijing 101318, P.R.China

Beijing Mediking Biopharm Co., Ltd.: Tel:+86-10-89753524/81760121/81769521; Address: Hongxianghong Incubator, Beiqijia Town, Changping district, Beijing, China

Hangzhou UNIWISE International Co.,Ltd.: Tel:+86-571-28819531; Address: E-19F, Dongqiing Building, 52 Qingchun Rd, Hangzhou, China

lotuschem: Tel:852-29738324; Address: Rm. 907. JCD116 Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong

Zhejiang Myjoy Import & Export Co.,Ltd.: Tel:86-571-28039808; Address: Rm.A 19F. Suit A Yaojiang Int'l Building 100 Moganshan Rd., Hangzhou, Zhejiang, China

TPNChina: Tel:+86-21-38726808; Address: No.2577,Dongfang Road,Weifang,China

Ipratropium bromide cas no:22254-24-6

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