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Bromocriptine mesylate cas no:22260-51-1

Synonyms: Bromocriptine mesilate (JP14);Bromocriptine mesylate (USP);Bromergon;Parlodel (TN);Pravidel;Prestwick_771;Ergotaman-3,6,18-trione, 2-bromo-12-hydroxy-2-(1-methylethyl)-5- (2-methylpropyl)-, (5alpha)-;2-Bromo-alpha-ergocryptine methanesulfonate;Bromocryptine mesylate;Parlodel;CB 154;Ergotaman-3',6',18-trione,2-bromo-12'- hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-,(5'R)-,monomethanesulfonate (salt);Bagren;

Identification
NameBromocriptine mesylate
CAS22260-51-1
SynonymsBromocriptine mesilate (JP14);Bromocriptine mesylate (USP);Bromergon;Parlodel (TN);Pravidel;Prestwick_771;Ergotaman-3,6,18-trione, 2-bromo-12-hydroxy-2-(1-methylethyl)-5- (2-methylpropyl)-, (5alpha)-;2-Bromo-alpha-ergocryptine methanesulfonate;Bromocryptine mesylate;Parlodel;CB 154;Ergotaman-3',6',18-trione,2-bromo-12'- hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-,(5'R)-,monomethanesulfonate (salt);Bagren;
EINECS(EC#)244-881-1
Molecular FormulaC32H40BrN5O5.CH4SO3
Molecular Weight654.5945
Chemical Properties
Appearancewhite solid
storage temp2-8°C
Safety Data

Hazard Xn: Harmful;
Risk R20/21/22
Safety

Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: cardiomyopathy. cerebral spinal fluid changes, distorted perceptions, hallucinations, headache, toxic psychosis. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of Br−, SOx, and NOx.
Safety Information of Bromocriptine mesylate (CAS NO.22260-51-1): 

Hazard Codes: Xn
Risk Statements:
20:  Harmful by inhalation
21:  Harmful in contact with skin
22:  Harmful if swallowed 
Safety Statements:
22:  Do not breathe dust
24:  Avoid contact with skin
25:  Avoid contact with eyes
36:  Wear suitable protective clothing


Toxicity
1.    

orl-wmn TDLo:650 µg/kg/9D-I:BAH,CVS

    AIMEAS    Annals of Internal Medicine. 118 (1993),199.
2.    

orl-cld TDLo:375 µg/kg

    JOPDAB    Journal of Pediatrics. 105 (1984),838.
3.    

orl-wmn TDLo:1 mg/kg/20D-I:BAH

    AJPSAO    American Journal of Psychiatry. 143 (1985),935.
4.    

orl-man TDLo:52 mg/kg/35W-I:CNS

    NEURAI    Neurology. 35 (1985),1193.
5.    

ivn-rat LD50:10,500 µg/kg

    YKYUA6    Yakkyoku. Pharmacy. 29 (1978),1231.
6.    

orl-mus LD50:2502 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 30 (1979),809.
7.    

ivn-mus LD50:189 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 30 (1979),809.
8.    

ivn-rbt LD50:8200 µg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),232.

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