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Bromocriptine mesylate cas no:22260-51-1

Synonyms: Bromocriptine mesilate (JP14);Bromocriptine mesylate (USP);Bromergon;Parlodel (TN);Pravidel;Prestwick_771;Ergotaman-3,6,18-trione, 2-bromo-12-hydroxy-2-(1-methylethyl)-5- (2-methylpropyl)-, (5alpha)-;2-Bromo-alpha-ergocryptine methanesulfonate;Bromocryptine mesylate;Parlodel;CB 154;Ergotaman-3',6',18-trione,2-bromo-12'- hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-,(5'R)-,monomethanesulfonate (salt);Bagren;

Identification
NameBromocriptine mesylate
CAS22260-51-1
SynonymsBromocriptine mesilate (JP14);Bromocriptine mesylate (USP);Bromergon;Parlodel (TN);Pravidel;Prestwick_771;Ergotaman-3,6,18-trione, 2-bromo-12-hydroxy-2-(1-methylethyl)-5- (2-methylpropyl)-, (5alpha)-;2-Bromo-alpha-ergocryptine methanesulfonate;Bromocryptine mesylate;Parlodel;CB 154;Ergotaman-3',6',18-trione,2-bromo-12'- hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-,(5'R)-,monomethanesulfonate (salt);Bagren;
EINECS(EC#)244-881-1
Molecular FormulaC32H40BrN5O5.CH4SO3
Molecular Weight654.5945
Chemical Properties
Appearancewhite solid
storage temp2-8°C
Safety Data

Hazard Xn: Harmful;
Risk R20/21/22
Safety

Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: cardiomyopathy. cerebral spinal fluid changes, distorted perceptions, hallucinations, headache, toxic psychosis. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of Br, SOx, and NOx.
Safety Information of Bromocriptine mesylate (CAS NO.22260-51-1): 

Hazard Codes: Xn
Risk Statements:
20:  Harmful by inhalation
21:  Harmful in contact with skin
22:  Harmful if swallowed 
Safety Statements:
22:  Do not breathe dust
24:  Avoid contact with skin
25:  Avoid contact with eyes
36:  Wear suitable protective clothing


Toxicity
1.    

orl-wmn TDLo:650 µg/kg/9D-I:BAH,CVS

    AIMEAS    Annals of Internal Medicine. 118 (1993),199.
2.    

orl-cld TDLo:375 µg/kg

    JOPDAB    Journal of Pediatrics. 105 (1984),838.
3.    

orl-wmn TDLo:1 mg/kg/20D-I:BAH

    AJPSAO    American Journal of Psychiatry. 143 (1985),935.
4.    

orl-man TDLo:52 mg/kg/35W-I:CNS

    NEURAI    Neurology. 35 (1985),1193.
5.    

ivn-rat LD50:10,500 µg/kg

    YKYUA6    Yakkyoku. Pharmacy. 29 (1978),1231.
6.    

orl-mus LD50:2502 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 30 (1979),809.
7.    

ivn-mus LD50:189 mg/kg

    YKYUA6    Yakkyoku. Pharmacy. 30 (1979),809.
8.    

ivn-rbt LD50:8200 µg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),232.

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