Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-[(4-pyridinylcarbonyl)oxy]-, (11b,16a)- cas no:2265-64-7

NamePregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-[(4-pyridinylcarbonyl)oxy]-, (11b,16a)-
CAS2265-64-7
SynonymsPregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16a-methyl-, 21-isonicotinate(7CI,8CI);Ausixone;Auxiloson;Dexamethasone 21-(4-pyridinecarboxylate);Dexamethasone 21-isonicotinate;Dexamethasone isonicotinate;HE 111;Isonicotinic acid dexamethasone-21 ester;Isonicotinic acid, 21-ester with 9-fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione;Ketoren;Pyridine-4-carboxylic acid 21-dexamethasone ester;Pyridine-4-carboxylic acid-(dexamethasone-21')-ester;Voren;
EINECS(EC#)218-866-5
Molecular FormulaC28H32 F N O6
Molecular Weight497.5552

refractive index1.608

Safety

Moderately toxic by intraperitoneal route. Experimental reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F⁻ and NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	281mg/kg (281mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
mouse	LD50	oral	3470mg/kg (3470mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
mouse	LD50	subcutaneous	3211mg/kg (3211mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat	LD50	intraperitoneal	313mg/kg (313mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat	LD50	oral	3562mg/kg (3562mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat	LD50	subcutaneous	3297mg/kg (3297mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.