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Trichothec-9-ene-3,4,15-triol,12,13-epoxy-, 4,15-diacetate, (3a,4b)- cas no:2270-40-8

Synonyms: Anguidin(7CI); Trichothec-9-ene-3a,4b,15-triol, 12,13-epoxy-,4,15-diacetate (8CI); Spiro[2,5-methano-1-benzoxepin-10,2'-oxirane],trichothec-9-ene-3,4,15-triol deriv.; 4,15-Di-O-acetylscirpenol;4,15-Diacetoxyscirp-9-en-3-ol; 4,15-Diacetoxyscirpen-3-ol;4,15-Diacetoxyscirpenol; 4b,15-Diacetoxy-12,13-epoxytrichothec-9-en-3a-ol; Anguidine; DAS; NSC 141537; NSC 177378;Scirp-9-ene-3a,4b,15-triol, 4,15-diacetate;Scirpenetriol 4,15-diacetate

Identification
NameTrichothec-9-ene-3,4,15-triol,12,13-epoxy-, 4,15-diacetate, (3a,4b)-
CAS2270-40-8
SynonymsAnguidin(7CI); Trichothec-9-ene-3a,4b,15-triol, 12,13-epoxy-,4,15-diacetate (8CI); Spiro[2,5-methano-1-benzoxepin-10,2'-oxirane],trichothec-9-ene-3,4,15-triol deriv.; 4,15-Di-O-acetylscirpenol;4,15-Diacetoxyscirp-9-en-3-ol; 4,15-Diacetoxyscirpen-3-ol;4,15-Diacetoxyscirpenol; 4b,15-Diacetoxy-12,13-epoxytrichothec-9-en-3a-ol; Anguidine; DAS; NSC 141537; NSC 177378;Scirp-9-ene-3a,4b,15-triol, 4,15-diacetate;Scirpenetriol 4,15-diacetate
EINECS(EC#)218-873-3
Molecular FormulaC19H26 O7
Molecular Weight 354.44
Chemical Properties
refractive index1.561
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard T+,T,Xn,F
Risk 26/27/28-36/38-36-20/21/22-11
Safety

A deadly poison by ingestion, inhalation, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by intraperitoneal route: muscle weakness, nausea or vomiting, and fever. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A skin irritant. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes: VeryT+ ToxicHarmfulXn Flammable
Risk Statements: 26/27/28-36/38-36-20/21/22-11
 R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed. 
R36/38: Irritating to eyes and skin. 
R36: Irritating to eyes. 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed. 
R11: Highly flammable.
Safety Statements: 53-45-36/37-16
 S53: Avoid exposure - obtain special instructions before use. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37: Wear suitable protective clothing and gloves. 
S16: Keep away from sources of ignition.
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: YD0112000
F: 10
HazardClass: 6.1(a)
PackingGroup: II


Toxicity

1.    

skn-gpg 284 ng MLD

    FAATDF    Fundamental and Applied Toxicology. 4 (1984),S124.
2.    

dns-rat-orl 3 mg/kg

    CALEDQ    Cancer Letters (Shannon, Ireland). 38 (1987),199.
3.    

dnd-mus-ivn 5600 µg/kg

    PAACA3    Proceedings of the American Association for Cancer Research. 19 (1978),65.
4.    

ipr-wmn TDLo:12 mg/kg/5 D:GIT

    CTRRDO    Cancer Treatment Reports. 63 (1979),789.
5.    

orl-rat LD50:7 mg/kg

    VHTODE    Veterinary and Human Toxicology. 25 (1983),335.
6.    

ipr-rat LD50:750 µg/kg

    DFSCDX    Developments in Food Science. 4 (1983),135.
7.    

ivn-rat LD50:1300 µg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),989.
8.    

orl-mus LD50:7300 µg/kg

    BIBIAU    Biotechnology and Bioengineering. 10 (1968),445.
9.    

ihl-mus LD50:11,300 µg/kg

    TOXID9    Toxicologist. 4 (1984),12.
10.    

ipr-mus LD50:7839 µg/kg

    NCISP*    National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .

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