Benzonitrile,2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-, hydrochloride (1:1) cas no:23093-74-5

NameBenzonitrile,2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-, hydrochloride (1:1)
CAS23093-74-5
SynonymsBenzonitrile,2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-, monohydrochloride (9CI);Benzonitrile, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-,monohydrochloride, (?à)-; Benzonitrile, o-[3-(tert-butylamino)-2-hydroxypropoxy]-,monohydrochloride, (?à)- (8CI); 1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropanehydrochloride; 1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol hydrochloride;Betriol; Bunitrolol hydrochloride; Ko 1366; Ko 1366 hydrochloride; Koe 1366;Stresson; dl-o-[2-Hydroxy-3-(tert-butylamino)propoxy]benzonitrile hydrochloride
EINECS(EC#)245-427-5
Molecular FormulaC14H20 N2 O2 . Cl H
Molecular Weight284.82

Safety

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. An experimental teratogen. When Bunitrolol hydrochloride (CAS NO.23093-74-5) is heated to decomposition, it emits toxic fumes of NO_x, CN⁻ and HCl. See also NITRILES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	36mg/kg (36mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
dog	LD50	oral	490mg/kg (490mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse	LD50	intraperitoneal	265mg/kg (265mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
mouse	LD50	oral	250mg/kg (250mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 25, 1981.
mouse	LD50	subcutaneous	542mg/kg (542mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rabbit	LD50	intravenous	26900ug/kg (26.9mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rabbit	LD50	oral	430mg/kg (430mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 25, 1981.
rat	LD50	intraperitoneal	222mg/kg (222mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rat	LD50	intravenous	69mg/kg (69mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rat	LD50	oral	639mg/kg (639mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rat	LD50	subcutaneous	902mg/kg (902mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.