Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,3',6'-dihydroxy- cas no:2321-07-5
Synonyms: Fluorescein(8CI);3,6-Dihydroxyspiro[xanthene-9,3'-phthalide];3',6'-Fluorandiol;Benzoic acid,2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-;C.I. 45350:1;D and C Yellow No. 7;3',6'-Dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one;C Yellow No. 7;Japan Yellow 201;Japan Yellow No. 201;Resorcinolphthalein;Yellow fluorescein;
NameSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,3',6'-dihydroxy-
CAS2321-07-5
SynonymsFluorescein(8CI);3,6-Dihydroxyspiro[xanthene-9,3'-phthalide];3',6'-Fluorandiol;Benzoic acid,2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-;C.I. 45350:1;D and C Yellow No. 7;3',6'-Dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one;C Yellow No. 7;Japan Yellow 201;Japan Yellow No. 201;Resorcinolphthalein;Yellow fluorescein;
EINECS(EC#)219-031-8
Molecular FormulaC20H12O5
Molecular Weight332.31
Appearanceorange-red crystalline powder
refractive index1.46355
storage temp−20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass3
Hazard Xi:Irritant;
Risk R36;R43
Safety
Hazard Codes of Fluorescein (CAS NO.2321-07-5): 
Xi
Risk Statements: 43-36/37/38
R43: May cause sensitization by skin contact.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-26-36/37/39-27
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S27: Take off immediately all contaminated clothing.
WGK Germany: 3
RTECS: LM5075000
F: 10-21
Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also FLUORESCEIN SODIUM.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| guinea pig |
LDLo |
unreported |
400mg/kg (400mg/kg) |
|
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. |
| man |
TDLo |
intravenous |
7143nL/kg (7143mL/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
American Journal of Ophthalmology. Vol. 126, Pg. 837, 1998. |
| mouse |
LD50 |
intravenous |
300mg/kg (300mg/kg) |
|
United States Patent Document. Vol. #4775625, |
| mouse |
LDLo |
unreported |
600mg/kg (600mg/kg) |
|
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. |
| rabbit |
LDLo |
intravenous |
300mg/kg (300mg/kg) |
|
International Journal of Leprosy and Other Mycobacterial Diseases. Vol. 2, Pg. 257, 1934. |
| rat |
LDLo |
intraperitoneal |
600mg/kg (600mg/kg) |
|
International Journal of Leprosy and Other Mycobacterial Diseases. Vol. 2, Pg. 257, 1934. |
