5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-7-[(2-cyanoacetyl)amino]-8-oxo-, sodium salt (1:1),(6R,7R)- cas no:23239-41-0

Name5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-7-[(2-cyanoacetyl)amino]-8-oxo-, sodium salt (1:1),(6R,7R)-
CAS23239-41-0
Synonyms5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-7-[(cyanoacetyl)amino]-8-oxo-, monosodium salt,(6R,7R)- (9CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-7-[(cyanoacetyl)amino]-8-oxo-, monosodium salt, (6R-trans)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-(2-cyanoacetamido)-3-(hydroxymethyl)-8-oxo-, acetate (ester), monosodium salt(8CI); 7-Cyanoacetylaminocephalosporanic acid sodium salt; Ba 36278; CIBA36278Ba; Cefacetrile sodium; Celospor; Celtol; Cephacetrile sodium;Cephacetrile-Na; Sodium3-(acetoxymethyl)-7-(2-cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Sodium 7-(2-cyanoacetamido)cephalosporanic acid; Sodium7-cyanacetamidocephalosporanate; Sodium cefacetril; Sodium cefacetrile; Sodiumcephacetrile; Vetimast
EINECS(EC#)245-513-2
Molecular FormulaC13H13 N3 O6 S . Na
Molecular Weight361.33

Safety

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intramuscular routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO_x, SO_x, Na₂O, and CN^?. See also NITRILES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intramuscular	500mg/kg (500mg/kg)	?	Antimicrobial Agents and Chemotherapy Vol. -, Pg. 150, 1970.
dog	LDLo	intravenous	6gm/kg (6000mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antimicrobial Agents and Chemotherapy Vol. -, Pg. 150, 1970.
dog	LDLo	oral	500mg/kg (500mg/kg)	?	Antimicrobial Agents and Chemotherapy Vol. -, Pg. 150, 1970.
guinea pig	LD50	subcutaneous	240mg/kg (240mg/kg)	?	Antimicrobial Agents and Chemotherapy Vol. -, Pg. 150, 1970.
mouse	LD50	intramuscular	8800mg/kg (8800mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 2, Pg. 1, 1976.
mouse	LD50	intravenous	3700mg/kg (3700mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1459, 1974.
mouse	LD50	oral	19gm/kg (19000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Yakkyoku. Pharmacy. Vol. 29, Pg. 487, 1978.
mouse	LD50	subcutaneous	7500mg/kg (7500mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1459, 1974.
rabbit	LDLo	intravenous	300mg/kg (300mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Antimicrobial Agents and Chemotherapy Vol. -, Pg. 150, 1970.
rat	LD50	intramuscular	7700mg/kg (7700mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 2, Pg. 1, 1976.
rat	LD50	intravenous	3100mg/kg (3100mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 2, Pg. 1, 1976.
rat	LD50	oral	15100mg/kg (15100mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 222, 1978.
rat	LD50	subcutaneous	11600mg/kg (11600mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Antimicrobial Agents and Chemotherapy Vol. -, Pg. 150, 1970.