23828-92-4|Ambroxol hydrochlorideProducts Supply - Chemical intermediates Network

Ambroxol hydrochloride cas no:23828-92-4

Synonyms: Hustless (TN);trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride;(2-amino-3,5-dibromo-phenyl)methyl-(4-hydroxycyclohexyl)azanium;18683-91-5;Ambroxol lozenge;Ambroxol Hcl;Altretamine;Mucoangin;Hustless;Mucolear;

Identification

NameAmbroxol hydrochloride
CAS23828-92-4
SynonymsHustless (TN);trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride;(2-amino-3,5-dibromo-phenyl)methyl-(4-hydroxycyclohexyl)azanium;18683-91-5;Ambroxol lozenge;Ambroxol Hcl;Altretamine;Mucoangin;Hustless;Mucolear;
EINECS(EC#)245-899-2
Molecular FormulaC₁₃H₁₉Br₂ClN₂O
Molecular Weight414.57

Chemical Properties

Appearancewhite to yellowish crystalline powder
storage temp2-8°C

Safety Data

Hazard Xn: Harmful;
Risk R22
Safety

Safety Information of?Ambroxol hydrochloride (CAS NO.23828-92-4):
Hazard Codes:Xn?
Risk Statements:22
22:Harmful if swallowed?
Safety Statements:36
36:Wear suitable protective clothing?
WGK Germany:3
RTECS:GV8423000
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Br^?, NO_x, and HCl.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intraperitoneal	125mg/kg (125mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
dog	LD50	oral	500mg/kg (500mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
guinea pig	LD50	intraperitoneal	280mg/kg (280mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
guinea pig	LD50	oral	1180mg/kg (1180mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse	LD50	intraperitoneal	268mg/kg (268mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse	LD50	intravenous	138mg/kg (138mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse	LD50	oral	2380mg/kg (2380mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
mouse	LD50	subcutaneous	1060mg/kg (1060mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.
rabbit	LD50	intravenous	64mg/kg (64mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rabbit	LD50	oral	2597mg/kg (2597mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rabbit	LDLo	intraperitoneal	400mg/kg (400mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
rat	LD50	intraperitoneal	262mg/kg (262mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: PERITONITIS	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rat	LD50	intravenous	100mg/kg (100mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rat	LD50	oral	4203mg/kg (4203mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.
rat	LD50	subcutaneous	1489mg/kg (1489mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.

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Ambroxol hydrochloride cas no:23828-92-4

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