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Tolnaftate cas no:2398-96-1

Synonyms: Dungistop;Focusan;Hi-Alarzin;NaphthiomateT;O-2-Naphthyl m,N-dimethylthiocarbanilate;Phytoderm;Pitrex;Sch 10144;Sporiline;Timoped;Tinactin;Tinaderm;Tineacure;Tniaderm;Tolnaphthate;Tolsanil;Tonoftal;Tritin;TolnaftateUSP;Carbamothioicacid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester (9CI);Carbanilic acid, m,N-dimethylthio-,O-2-naphthyl ester (7CI,8CI);2-Naphthyl N-methyl-N-(3-tolyl)thiocarbamate;2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate;2-NaphthylN-methyl-N-m-tolylthiocarbamate;Aftate;Chinofungin;Dermoxin;Dr. Scholl'sAthlete's Foot Spray;

Identification
NameTolnaftate
CAS2398-96-1
SynonymsDungistop;Focusan;Hi-Alarzin;NaphthiomateT;O-2-Naphthyl m,N-dimethylthiocarbanilate;Phytoderm;Pitrex;Sch 10144;Sporiline;Timoped;Tinactin;Tinaderm;Tineacure;Tniaderm;Tolnaphthate;Tolsanil;Tonoftal;Tritin;TolnaftateUSP;Carbamothioicacid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester (9CI);Carbanilic acid, m,N-dimethylthio-,O-2-naphthyl ester (7CI,8CI);2-Naphthyl N-methyl-N-(3-tolyl)thiocarbamate;2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate;2-NaphthylN-methyl-N-m-tolylthiocarbamate;Aftate;Chinofungin;Dermoxin;Dr. Scholl'sAthlete's Foot Spray;
EINECS(EC#)219-266-6
Molecular FormulaC19H17NOS
Molecular Weight307.41
Chemical Properties
Appearancewhite powder
refractive index1.697
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
HazardclassIRRITANT
Safety Data

Safety

Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of SOx and NOx. A fungicide used to control athlete’s foot. See also Esters and Carbamates.
WGK Germany: 2
RTECS: FD8891300


Toxicity
dog LD50 oral > 14gm/kg (14000mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 615, 1964.
guinea pig LD50 oral > 4gm/kg (4000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.
mouse LD50 intraperitoneal 120mg/kg (120mg/kg)   Drug and Chemical Toxicology. Vol. 13, Pg. 195, 1990.
mouse LD50 intravenous 4800mg/kg (4800mg/kg)   Drugs in Japan Vol. 6, Pg. 530, 1982.
mouse LD50 oral 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 530, 1982.
mouse LD50 subcutaneous > 6gm/kg (6000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.
rabbit LD intravenous > 50mg/kg (50mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.
rat LD50 oral > 6gm/kg (6000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.

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