24219-97-4|Dibenzo[c,f]pyrazino[1,2-a]azepine,1,2,3,4,10,14b-hexahydro-2-methyl-Products Supply

Dibenzo[c,f]pyrazino[1,2-a]azepine,1,2,3,4,10,14b-hexahydro-2-methyl- cas no:24219-97-4

Synonyms: (?à)-Mianserin; Mianserin;Mianserine

Identification

NameDibenzo[c,f]pyrazino[1,2-a]azepine,1,2,3,4,10,14b-hexahydro-2-methyl-
CAS24219-97-4
Synonyms(?à)-Mianserin; Mianserin;Mianserine
EINECS(EC#)246-088-6
Molecular FormulaC18H20 N2
Molecular Weight264.40

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Safety

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: agranulocytosis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	9mg/kg/3W-I (9mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: OTHER CHANGES	Medical Journal of Australia. Vol. 140, Pg. 166, 1984.
mouse	LD50	intraperitoneal	130mg/kg (130mg/kg)		Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 40, Pg. 235, 1983.
mouse	LD50	oral	365mg/kg (365mg/kg)		Drug Development Research. Vol. 3, Pg. 357, 1983.
rat	LD50	oral	925mg/kg (925mg/kg)		Journal of International Medical Research. Vol. 13, Pg. 77, 1985.
women	TDLo	oral	1200ug/kg (1.2mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: CHANGE IN RATE	Human & Experimental Toxicology. Vol. 10, Pg. 383, 1991.
women	TDLo	oral	25mg/kg/6W-I (25mg/kg)	BLOOD: AGRANULOCYTOSIS	British Medical Journal. Vol. 291, Pg. 1375, 1985.
women	TDLo	oral	876mg/kg/2Y-I (876mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: WAKEFULNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Italian Journal of Neurological Sciences. Vol. 9, Pg. 167, 1988.

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Dibenzo[c,f]pyrazino[1,2-a]azepine,1,2,3,4,10,14b-hexahydro-2-methyl- cas no:24219-97-4

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