24305-27-9|ProtirelinProducts Supply - Chemical intermediates Network

Protirelin cas no:24305-27-9

Synonyms: Thyrotropin-releasingfactor (8CI);(Pyro)-L-glutamic acid-L-histidine-L-proline-NH2;Antepan;L-Pyroglutamyl-L-histidyl-L-prolinamide;L-Pyroglutamyl-L-histidyl-L-prolineamide;Lopremone;Prem;Relefact TRH;Rifotironin;Stimu TSH;Synthetic TRF;Synthetic TSH-releasingfactor;Synthetic TSH-releasing hormone;Synthetic thyrotropin-releasingfactor;Synthetic thyrotropin-releasing hormone;TRF;TRH;TSH-RF;TSH-releasing hormone;Thypinone;Thyrefact;Thyroidreleasing hormone;Thyroid-stimulating hormone-releasing factor;Thyroliberin;Thyrotropic hormone-releasing factor;Thyrotropic releasing hormone;Thyrotropic-releasing factor;Thyrotropin-releasing hormone;Thyrotropin-Releasing Hormone: TRH;

Identification

NameProtirelin
CAS24305-27-9
SynonymsThyrotropin-releasingfactor (8CI);(Pyro)-L-glutamic acid-L-histidine-L-proline-NH2;Antepan;L-Pyroglutamyl-L-histidyl-L-prolinamide;L-Pyroglutamyl-L-histidyl-L-prolineamide;Lopremone;Prem;Relefact TRH;Rifotironin;Stimu TSH;Synthetic TRF;Synthetic TSH-releasingfactor;Synthetic TSH-releasing hormone;Synthetic thyrotropin-releasingfactor;Synthetic thyrotropin-releasing hormone;TRF;TRH;TSH-RF;TSH-releasing hormone;Thypinone;Thyrefact;Thyroidreleasing hormone;Thyroid-stimulating hormone-releasing factor;Thyroliberin;Thyrotropic hormone-releasing factor;Thyrotropic releasing hormone;Thyrotropic-releasing factor;Thyrotropin-releasing hormone;Thyrotropin-Releasing Hormone: TRH;
EINECS(EC#)246-143-4
Molecular FormulaC₁₆H₂₂N₆O₄
Molecular Weight362.38368

Chemical Properties

AppearanceWhite or almost white powder
refractive index1.615
storage temp?20°C

Safety Data

Safety

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Safety information of? Protirelin (CAS NO.24305-27-9):
Safety Statements: 22,24/25
S22:Do not breathe dust.?
S24/25:Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: TW3580000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intravenous	5333ng/kg/2M- (0.005333mg/kg)	BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	British Medical Journal. Vol. 287, Pg. 532, 1983.
man	TDLo	intravenous	5714ng/kg/1M- (0.005714mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Medical Journal of Australia. Vol. 143, Pg. 264, 1985.
mouse	LD50	intravenous	921mg/kg (921mg/kg)	?	Drugs in Japan Vol. 6, Pg. 727, 1982.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 727, 1982.
mouse	LD50	subcutaneous	> 20gm/kg (20000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 727, 1982.
rat	LD50	intravenous	514mg/kg (514mg/kg)	?	Drugs in Japan Vol. 6, Pg. 727, 1982.
rat	LD50	oral	> 5gm/kg (5000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 727, 1982.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 727, 1982.
women	TDLo	intravenous	8ug/kg/2M-C (0.008mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	British Medical Journal. Vol. 287, Pg. 532, 1983. ?

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Protirelin cas no:24305-27-9

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