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Clindamycin phosphate cas no:24729-96-2

Synonyms: U 28508;Dalacin-S;Cleocin phosphate;Dalacin T;Cleocin T (TN);L-threo-R-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1- methyl-4-propyl-2-pyrrolidinyl]carbonyl]- amino]-1-thio-,2-(dihydrogen phosphate);Dalacin P;[6-[2-chloro-1-[(1-methyl-4-propyl-pyrrolidine-2-carbonyl)amino]propyl]-4,5-dihydroxy-2-methylsulfanyl-oxan-3-yl]oxyphosphonic acid;Cleocin T;Clindamycin 2-phosphate;

Identification
NameClindamycin phosphate
CAS24729-96-2
SynonymsU 28508;Dalacin-S;Cleocin phosphate;Dalacin T;Cleocin T (TN);L-threo-R-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1- methyl-4-propyl-2-pyrrolidinyl]carbonyl]- amino]-1-thio-,2-(dihydrogen phosphate);Dalacin P;[6-[2-chloro-1-[(1-methyl-4-propyl-pyrrolidine-2-carbonyl)amino]propyl]-4,5-dihydroxy-2-methylsulfanyl-oxan-3-yl]oxyphosphonic acid;Cleocin T;Clindamycin 2-phosphate;
EINECS(EC#)246-433-0
Molecular FormulaC18H34ClN2O8PS
Molecular Weight504.962921
Chemical Properties
AppearanceWhite solid
refractive index122 ° (C=1, H2O)
storage temp2-8°C
Safety Data

Hazard Xi: Irritant;
Risk R22
Safety

Safety Information of?Clindamycin-2-phosphate (CAS NO.24729-96-2):?
Hazard Codes:?HarmfulXn,Xi
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 36-26?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: GF2625000
Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human systemic effects by intravenous route: pulse rate increase, blood pressure lowering. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl?, POx, SOx, and NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 1100mg/kg (1100mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 intraperitoneal 784mg/kg (784mg/kg) ? Drugs under Experimental and Clinical Research. Vol. 3, Pg. 79, 1977.
mouse LD50 intravenous 820mg/kg (820mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 oral 2539mg/kg (2539mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 subcutaneous 1036mg/kg (1036mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat LD50 intramuscular > 3500mg/kg (3500mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 691, 1983.
rat LD50 intraperitoneal 745mg/kg (745mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat LD50 intravenous 321mg/kg (321mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat LD50 oral 1832mg/kg (1832mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toxicology and Applied Pharmacology. Vol. 27, Pg. 308, 1974.
rat LD50 subcutaneous 3861mg/kg (3861mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
women TDLo intravenous 12mg/kg (12mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: OTHER CHANGES

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Southern Medical Journal. Vol. 75, Pg. 768, 1982.

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