24729-96-2|Clindamycin phosphateProducts Supply - Chemical intermediates Network

Clindamycin phosphate cas no:24729-96-2

Synonyms: U 28508;Dalacin-S;Cleocin phosphate;Dalacin T;Cleocin T (TN);L-threo-R-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1- methyl-4-propyl-2-pyrrolidinyl]carbonyl]- amino]-1-thio-,2-(dihydrogen phosphate);Dalacin P;[6-[2-chloro-1-[(1-methyl-4-propyl-pyrrolidine-2-carbonyl)amino]propyl]-4,5-dihydroxy-2-methylsulfanyl-oxan-3-yl]oxyphosphonic acid;Cleocin T;Clindamycin 2-phosphate;

Identification

NameClindamycin phosphate
CAS24729-96-2
SynonymsU 28508;Dalacin-S;Cleocin phosphate;Dalacin T;Cleocin T (TN);L-threo-R-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1- methyl-4-propyl-2-pyrrolidinyl]carbonyl]- amino]-1-thio-,2-(dihydrogen phosphate);Dalacin P;[6-[2-chloro-1-[(1-methyl-4-propyl-pyrrolidine-2-carbonyl)amino]propyl]-4,5-dihydroxy-2-methylsulfanyl-oxan-3-yl]oxyphosphonic acid;Cleocin T;Clindamycin 2-phosphate;
EINECS(EC#)246-433-0
Molecular FormulaC₁₈H₃₄ClN₂O₈PS
Molecular Weight504.962921

Chemical Properties

AppearanceWhite solid
refractive index122 ° (C=1, H2O)
storage temp2-8°C

Safety Data

Hazard Xi: Irritant;
Risk R22
Safety

Safety Information of?Clindamycin-2-phosphate (CAS NO.24729-96-2):?
Hazard Codes:? Harmful Xn,Xi
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 36-26?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: GF2625000
Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human systemic effects by intravenous route: pulse rate increase, blood pressure lowering. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl^?, PO_x, SO_x, and NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intramuscular	1100mg/kg (1100mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse	LD50	intraperitoneal	784mg/kg (784mg/kg)	?	Drugs under Experimental and Clinical Research. Vol. 3, Pg. 79, 1977.
mouse	LD50	intravenous	820mg/kg (820mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse	LD50	oral	2539mg/kg (2539mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse	LD50	subcutaneous	1036mg/kg (1036mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat	LD50	intramuscular	> 3500mg/kg (3500mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 691, 1983.
rat	LD50	intraperitoneal	745mg/kg (745mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat	LD50	intravenous	321mg/kg (321mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat	LD50	oral	1832mg/kg (1832mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toxicology and Applied Pharmacology. Vol. 27, Pg. 308, 1974.
rat	LD50	subcutaneous	3861mg/kg (3861mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
women	TDLo	intravenous	12mg/kg (12mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Southern Medical Journal. Vol. 75, Pg. 768, 1982.

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Clindamycin phosphate cas no:24729-96-2

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