Polyinosinic acid-polycytidylic acid cas no:24939-03-5

NamePolyinosinic acid-polycytidylic acid
CAS24939-03-5
SynonymsNSC-120949;PolyC;POLY I:C;polycytidylic acid;Polyinosinic acid Polycytidylic acid;Poly(rI).(rC);Polyinosinic-polycytidylic acid complex;Poly (I:C);Polycytidysic acid;Poly I:poly C;5-Inosinic acid homopolymer-5-cytidylic acid homopolymer complex (1:1);Poly (I).poly(C);Polyinosinic-polycyticylic acid complex;Poly IC;POLY I-C;Polyribocytidylic acid-polyriboinosinic acid complex;5-Inosinic acid, homopolymer, complex with 5-cytidylic acid homopolymer (1:1) (9CI);Poly(I).poly(C); Poly(I).poly(C) complex;Polyriboinosinic-polyribocytidylic acid complex;Polyinosinic-polycytidylic acid;Polyriboinosinic acid-polyribocytidylic acid complex;Polyinosinic acid:polycytidylic acid;Polyinosinate:polycytidylate;Polyriboinosinic-polyribocytidylic acid;5-Inosinic acid, homopolymer, complex with 5-cytidylic acid homopolymer (1:1);Poly(I).poly(C);Poly(I).poly(C) complex;[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid; [3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic acid;Polyriboinosinic acid:polyribocytidylic acid;Poly (rI:rC);Polyinosinic:polycytidylic acid copolymer;Polyinosinic:polycytidylic acid;Polyinosinic acid.polycytidylic acid;Polyriboinosinic: polyribocytidylic acid;Poly(rI).poly(rC);Polycytidylic-polyinosinic acid;Poly C poly I;Poly(cytidylic acid)-poly(inosinic acid);Polyriboinosinic acid:polyribocyticylic acid;Polyinosinic acid:polycytidylic acid complex;Poly (rI).poly(rC);PI:C;Poly (rI).(rC);Poly(I+C);Poly (rI)-poly(rC);Polyinosinate-polycytidylate complex;Poly (cytidylic acid)-poly(inosinic acid);Poly 1-poly-c;5-Inosinic acid, polymers, complex with 5-cytidylic acid polymers (1:1) (8CI);Poly(I:C) (VAN);Poly rI:poly rC;5-Inosinic acid, polymers, complex with 5-cytidylic acid polymers (1:1);
Molecular Formula(C₁₀H₁₃N₄O₈P)_x^.(C₉H₁₄N₃O₈P)_x
Molecular Weight671.41

storage temp−20°C

Safety

Poison by intraperitoneal and intravenous routes. Experimental reproductive effects. Human mutation data reported. An eye irritant. When Polyinosinic:polycytidylic acid copolymer (CAS NO.24939-03-5) is heated to decomposition ,it emits acrid smoke and irritating fumes.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LDLo	intravenous	15mg/kg (15mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE	Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse	LD50	intraperitoneal	35mg/kg (35mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse	LD50	intravenous	9500ug/kg (9.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse	LD50	parenteral	20mg/kg (20mg/kg)	BEHAVIORAL: EXCITEMENT	Nature. Vol. 223, Pg. 715, 1969.
rabbit	LD50	intravenous	220ug/kg (0.22mg/kg)	VASCULAR: OTHER CHANGES BLOOD: HEMORRHAGE	Voprosy Virusologii. Problems of Virology. Vol. 23(2), Pg. 201, 1978.
rat	LD50	intraperitoneal	365mg/kg (365mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: NAUSEA OR VOMITING	Toxicology and Applied Pharmacology. Vol. 18, Pg. 220, 1971.
rat	LD50	intravenous	185mg/kg (185mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: NAUSEA OR VOMITING	Toxicology and Applied Pharmacology. Vol. 18, Pg. 220, 1971.