25122-46-7|Clobetasol propionateProducts Supply - Chemical intermediates Network

Clobetasol propionate cas no:25122-46-7

Synonyms: Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11b,17-dihydroxy-16b-methyl-,17-propionate (8CI);21-Chloro-21-deoxybetamethasone 17-propionate;CCl 4725;CGP 9555;Clobederm;Clobesol;Clobetasol 17-propionate;Clobex;Dermoval;Dermovate;Dermoxinale;GR 2/925;Karison;Olux;Skin Cap;Temovate;Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11b,16b)-;

Identification

NameClobetasol propionate
CAS25122-46-7
SynonymsPregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11b,17-dihydroxy-16b-methyl-,17-propionate (8CI);21-Chloro-21-deoxybetamethasone 17-propionate;CCl 4725;CGP 9555;Clobederm;Clobesol;Clobetasol 17-propionate;Clobex;Dermoval;Dermovate;Dermoxinale;GR 2/925;Karison;Olux;Skin Cap;Temovate;Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11b,16b)-;
EINECS(EC#)246-634-3
Molecular FormulaC₂₅H₃₂ClFO₅
Molecular Weight466.969983

Chemical Properties

AppearanceWhite Crystalline Powder
refractive index1.56

Safety Data

Hazard Xi:Irritant
Risk R36/37/38
Safety

Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin??
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36:Wear suitable protective clothing
Poison by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F^? and Cl^?.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	118mg/kg (118mg/kg)	?	Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse	LD50	oral	> 3gm/kg (3000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse	LD50	subcutaneous	81700ug/kg (81.7mg/kg)	?	Drugs in Japan Vol. 6, Pg. 241, 1982.
rat	LD50	intraperitoneal	351mg/kg (351mg/kg)	?	Drugs in Japan Vol. 6, Pg. 241, 1982.
rat	LD50	oral	> 3gm/kg (3000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 241, 1982.
rat	LD50	subcutaneous	366mg/kg (366mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 1066, 1978.

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Clobetasol propionate cas no:25122-46-7

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