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Home > products > Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16b)-

Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16b)- cas no:25122-57-0

Synonyms: Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-17-hydroxy-16b-methyl-, butyrate (8CI);Butyric acid, ester with21-chloro-9-fluoro-17-hydroxy-16b-methylpregna-1,4-diene-3,11,20-trione (8CI);CCl 5537;Clobetasone17-butyrate;Emovate;Eumovate;GR 2/1214;Kindavate;Molivate;SN 203;

Identification
NamePregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16b)-
CAS25122-57-0
SynonymsPregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-17-hydroxy-16b-methyl-, butyrate (8CI);Butyric acid, ester with21-chloro-9-fluoro-17-hydroxy-16b-methylpregna-1,4-diene-3,11,20-trione (8CI);CCl 5537;Clobetasone17-butyrate;Emovate;Eumovate;GR 2/1214;Kindavate;Molivate;SN 203;
EINECS(EC#)246-635-9
Molecular FormulaC26H32ClFO5
Molecular Weight478.99
Chemical Properties
refractive index1.551
Safety Data

Hazard Xn:Harmful
Risk R40
Safety

Hazard Codes:  Xn
Risk Statements:  40
40:  Limited evidence of a carcinogenic effect 
Safety Statements:  22-36
22:  Do not breathe dust 
36: Clobetasone butyrate (25122-57-0) used,please wear suitable protective clothing .
RTECS : TU4154083


Toxicity

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

mouse

LD50

intraperitoneal

500mg/kg (500mg/kg)

 

Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.

mouse

LD50

oral

> 6gm/kg (6000mg/kg)

behavioral: somnolence (general depressed activity)
blood: changes in spleen
skin and appendages (skin): hair: other

Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984.

mouse

LD50

subcutaneous

> 3600mg/kg (3600mg/kg)

behavioral: somnolence (general depressed activity)
blood: changes in spleen
skin and appendages (skin): hair: other

Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984.

rat

LD50

intraperitoneal

1510mg/kg (1510mg/kg)

endocrine: other changes
blood: changes in spleen
blood: other changes

Journal of Toxicological Sciences. Vol. 5, Pg. 45, 1980.

rat

LD50

oral

> 6gm/kg (6000mg/kg)

behavioral: somnolence (general depressed activity)
blood: changes in spleen
skin and appendages (skin): hair: other

Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984.

rat

LD50

subcutaneous

> 2600mg/kg (2600mg/kg)

behavioral: somnolence (general depressed activity)
blood: changes in spleen
skin and appendages (skin): hair: other

Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984.

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