Doxorubicin hydrochloride cas no:25316-40-9
Synonyms: 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S,10S)- (9CI);5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-;Adriamycin, hydrochloride (8CI);ADM hydrochloride;ADR;Adriablastina CS;Adriacin;Adriamycin;Adriblastin;Adriblastina;Adriblastina RD;DOX HCl;FI 106;FI 6804;Lipo-Dox;
NameDoxorubicin hydrochloride
CAS25316-40-9
Synonyms5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S,10S)- (9CI);5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-;Adriamycin, hydrochloride (8CI);ADM hydrochloride;ADR;Adriablastina CS;Adriacin;Adriamycin;Adriblastin;Adriblastina;Adriblastina RD;DOX HCl;FI 106;FI 6804;Lipo-Dox;
EINECS(EC#)246-818-3
Molecular FormulaC27H30ClNO11
Molecular Weight579.99
AppearanceOrange-Red Crystalline Solid
storage temp2-8°C
Hazard T: Toxic;T+: Very toxic;
Risk R45;R22
Safety
Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human systemic effects: changes in kidney tubules, cardiomyopathy, acute pulmonary edema. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antineoplastic and immunosuppressive agent. When heated to decomposition it emits toxic fumes of NOx and HCl.
Hazard Codes:?
T,
T+
Risk Statements: 45-22-40-26/27/28
R45:May cause cancer.?
R22:Harmful if swallowed.?
R40:Limited evidence of a carcinogenic effect.?
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 53-45-36/37/39-22-7/9
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S22:Do not breathe dust.?
S7:Keep container tightly closed.?
S9:Keep container in a well-ventilated place.
WGK Germany: 3
RTECS: QI9295900
F: 10-21
| 1. |
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dni-mus:leu 1500?nmol/L
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JMCMAR ?? Journal of Medicinal Chemistry. 22 (1979),912. |
| 2. |
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oms-mus:leu 580?nmol/L
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JMCMAR ?? Journal of Medicinal Chemistry. 22 (1979),912. |
| 3. |
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dni-ckn:emb 900?nmol/L
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JMCMAR ?? Journal of Medicinal Chemistry. 26 (1983),638. |
| 4. |
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ivn-man LDLo:2571?μg/kg/3W-I:KID
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AIMDAP ?? Archives of Internal Medicine. 137 (1977),385. |
| 5. |
??? |
ivn-man TDLo:12?mg/kg/26W-I:CVS,PUL
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AIMEAS ?? Annals of Internal Medicine. 106 (1987),814. |
| 6. |
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ipr-rat LD50:16,030?μg/kg
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YAKUD5 ?? Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),359. |
| 7. |
??? |
scu-rat LD50:21,800?μg/kg
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NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),506. |
| 8. |
??? |
ivn-rat LD50:13,100?μg/kg
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??? |
NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),506. |
| 9. |
??? |
ims-rat LD50:16?mg/kg
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??? |
NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),506. |
| 10. |
??? |
orl-m
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