Indolizino[1,2-b]quinoline-7-aceticacid, a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-,sodium salt (1:1), (aS)- cas no:25387-67-1

NameIndolizino[1,2-b]quinoline-7-aceticacid, a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-,sodium salt (1:1), (aS)-
CAS25387-67-1
Synonyms21,22-Secocamptothecin-21-oicacid, monosodium salt (8CI); Indolizino[1,2-b]quinoline-7-acetic acid, a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-,monosodium salt, (S)-; Indolizino[1,2-b]quinoline-7-acetic acid, a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-,monosodium salt, (aS)- (9CI); 20(S)-Camptothecin sodium salt; Camptothecin sodium;Camptothecine sodium; NSC 100880; Sodium camptothecin
Molecular FormulaC20H18 N2 O5 . Na
Molecular Weight370.36

Safety

Poison by ingestion and intravenous routes. Human systemic effects by intravenous route: reduction in the number of white blood cells (leukopenia), reduction in the number of blood platelets (thrombocytopenia), and changes in blood cell count. When heated to decomposition, Camptothecin, sodium salt (CAS NO.25387-67-1) emits toxic fumes of NO_x and Na₂O.

1.		ivn-hmn TDLo:2500 µg/kg/7D-I:BLD		CCROBU    Cancer Chemotherapy Reports, Part 1. 56 (1972),515.
2.		orl-mus LD50:27 mg/kg		PMDCAY    Progress in Medical Chemistry. 9 (1973),1.
3.		ivn-mus LD50:57 mg/kg		PMDCAY    Progress in Medical Chemistry. 9 (1973),1.