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Naproxen sodium cas no:26159-34-2

Synonyms: 2-Naphthaleneaceticacid, 6-methoxy-a-methyl-, sodiumsalt, (S)-;2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, L-(-)- (8CI);(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid sodium salt;Aflaxen;Agilxen;Aleve;Anaprox;Anaprox DS;Apranax;Apraxin;Dafloxen;Duk-F;Flanax;Flanax Forte;Gynestrel;Lefaine;Licorax;Miranax;Naprelan;Naprogesic;

Identification
NameNaproxen sodium
CAS26159-34-2
Synonyms2-Naphthaleneaceticacid, 6-methoxy-a-methyl-, sodiumsalt, (S)-;2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, L-(-)- (8CI);(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid sodium salt;Aflaxen;Agilxen;Aleve;Anaprox;Anaprox DS;Apranax;Apraxin;Dafloxen;Duk-F;Flanax;Flanax Forte;Gynestrel;Lefaine;Licorax;Miranax;Naprelan;Naprogesic;
EINECS(EC#)247-486-2
Molecular FormulaC14H13O3.Na
Molecular Weight252.24
Chemical Properties
Appearancewhite powder
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn:;
Risk R22
Safety

In August 2006, the Journal Birth Defects Research Part B published results indicating that pregnant women who take NSAIDs including naproxen in the first trimester run an increased risk of having a child with congenital birth defects, particularly heart anomalies
IP110 Naproxen Tablets: Like other NSAIDs, naproxen can inhibit the excretion of sodium and LITHIUM. Extreme care must be taken by those who use this drug along with LITHIUM supplements. Naproxen is also not recommended for use with NSAIDs of the salicylate family or with anticoagulants? Naproxen preparations containing sodium are not recommended for use in patients with sodium-sensitive hypertension, due to potential adverse effects on blood pressure in this small subset of hypertensive.
Safety Information of Naproxen sodium (CAS NO.26159-34-2):
Hazard Codes: XnHarmful
Risk Statements: 22??
R22:Harmful if swallowed.
RIDADR: 3249
RTECS: QJ1047000
HazardClass: 6.1(b)
PackingGroup: III


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 600mg/kg/30D- (600mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
American Journal of Diseases of Children. Vol. 142, Pg. 524, 1988.

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