10H-Phenothiazine-2-carbonitrile,10-[3-(4-hydroxy-1-piperidinyl)propyl]- cas no:2622-26-6

Name10H-Phenothiazine-2-carbonitrile,10-[3-(4-hydroxy-1-piperidinyl)propyl]-
CAS2622-26-6
SynonymsPhenothiazine-2-carbonitrile,10-[3-(4-hydroxypiperidino)propyl]- (6CI,7CI,8CI); 10-[3-(4-Hydroxypiperidino)propyl]phenothiazine-2-carbonitrile;2-Cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine;2-Cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine; Aolept; Bayer 1409; FI6145; Nelactil; Nemactil; Neulactil; Neuleptil; Periciazine; Periciazinum;Pericyazine; Properciazine; Propericiazine; Propericyazine; RP 8909; SKF 20716
EINECS(EC#)220-071-3
Molecular FormulaC21H23 N3 O S
Molecular Weight365.53

refractive index1.694
storage temp2-8°C

Hazard Xn: Harmful;
Risk R22
Safety

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN⁻, NO_x, and SO_x. See also NITRILES.
Hazard Codes of Propericiazine (CAS NO.2622-26-6): Xn
Risk Statements: 22-36/37/38-20/21/22 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	100mg/kg (100mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
mouse	LD50	intraperitoneal	115mg/kg (115mg/kg)		Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
mouse	LD50	intravenous	27700ug/kg (27.7mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 74, 1967.
mouse	LD50	oral	530mg/kg (530mg/kg)		Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
mouse	LD50	subcutaneous	375mg/kg (375mg/kg)		Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
rat	LD50	intraperitoneal	85mg/kg (85mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.
rat	LD50	intravenous	35mg/kg (35mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.
rat	LD50	oral	395mg/kg (395mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rat	LD50	subcutaneous	1200mg/kg (1200mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.