Darvon-N cas no:26570-10-5

NameDarvon-N
CAS26570-10-5
Synonymsd-PROPOXYPHENE NAPSYLATE HYDRATE;S-9700;d-4-DIMETHYLAMINO-3-METHYL-1,2-DIPHENYL-2-PROPIONOXYBUTANENAPHTHALENE-2-SULPHONATE HYDRATE;
Molecular FormulaC10H8O3S . C22H29NO2 . H2O
Molecular Weight565.72

Hazard 3
Safety

Poison by ingestion, subcutaneous, and intraperitoneal routes. When Darvon-N (CAS NO.26570-10-5) is heated to decomposition ,it emits toxic fumes of SO_x and NO_x. See also d-PROPOXYPHENE HYDROCHLORIDE and SULFONATES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	100mg/kg (100mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
cat	LDLo	subcutaneous	800mg/kg (800mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
dog	LDLo	oral	800mg/kg (800mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
dog	LDLo	subcutaneous	1200mg/kg (1200mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
guinea pig	LDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
guinea pig	LDLo	subcutaneous	800mg/kg (800mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
mouse	LD50	intraperitoneal	171mg/kg (171mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
mouse	LD50	oral	973mg/kg (973mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 359, 1971.
mouse	LD50	subcutaneous	749mg/kg (749mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971.
rabbit	LDLo	oral	800mg/kg (800mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
rat	LD50	intraperitoneal	56mg/kg (56mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971.
rat	LD50	oral	485mg/kg (485mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971.
rat	LD50	subcutaneous	169mg/kg (169mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971.