26615-21-4|Ethanamine,2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-Products Supply

Ethanamine,2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl- cas no:26615-21-4

Synonyms: Ethylamine,2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl- (8CI); Dibenzo[b,f]thiepin,ethanamine deriv.; Lodopin; Nipolept; Zotepine

Identification

NameEthanamine,2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-
CAS26615-21-4
SynonymsEthylamine,2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl- (8CI); Dibenzo[b,f]thiepin,ethanamine deriv.; Lodopin; Nipolept; Zotepine
Molecular FormulaC18H18 Cl N O S
Molecular Weight331.88

Chemical Properties

refractive index1.655

Safety Data

Safety

Poison by ingestion, intravenous, subcutaneous and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of SO_x, Cl⁻, and NO_x. Used as a tranquilizer.

Toxicity

1.	orl-rat LD50:306 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 29 (1979),1600.
2.	ipr-rat LD50:97 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 29 (1979),1600.
3.	scu-rat LD50:1290 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 29 (1979),1600.
4.	ivn-rat LD50:36,800 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. (Yakugyo Jiho Co., Ltd., Tokyo, Japan) 6,APP-12 ,1982.
5.	orl-mus LD50:108 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 29 (1979),1600.
6.	ipr-mus LD50:36,200 µg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 29 (1979),1600.
7.	scu-mus LD50:84,900 µg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 29 (1979),1600.
8.	ivn-mus LD50:43,300 µg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 29 (1979),1600.
9.	ivn-dog LD50:26,600 µg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 29 (1979),1600.
10.	orl-rbt LD50:250 mg/kg

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Ethanamine,2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl- cas no:26615-21-4

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