Ethanone,1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,hydrochloride (1:1) cas no:26786-32-3

NameEthanone,1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,hydrochloride (1:1)
CAS26786-32-3
SynonymsAcetophenone,4'-chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,monohydrochloride (8CI); Ethanone,1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,monohydrochloride (9CI); Gamanil; Gamonil; Leo 640 hydrochloride; Lofepraminehydrochloride; Lopramine hydrochloride; Timelit; Tymelyt; WHR 2908A
EINECS(EC#)248-002-2
Molecular FormulaC26H27 Cl N2 O . Cl H
Molecular Weight455.41932

Appearanceoff-white solid
storage temp2-8°C

Safety

Poison by intraperitoneal route. Experimental reproductive effects. An experimental teratogen. Mutation data reported. When Iopramine hydrochloride (CAS NO.26786-32-3) is heated to decomposition, it emits toxic fumes of NO_x and HCl. See also AMINES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	920mg/kg (920mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 877, 1976.
mouse	LD50	subcutaneous	> 1gm/kg (1000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
rat	LD50	intraperitoneal	> 1gm/kg (1000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 877, 1976.
rat	LD50	subcutaneous	> 1gm/kg (1000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.