Homoharringtonine cas no:26833-87-4
Synonyms: Cephalotaxine,4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]-;Homoharringtonine (8CI);CGX 635;Ceflatonin;Myelostat;NSC 141633;Omacetaxine mepesuccinate;Ephalotaxine, 4-methyl(2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester);
NameHomoharringtonine
CAS26833-87-4
SynonymsCephalotaxine,4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]-;Homoharringtonine (8CI);CGX 635;Ceflatonin;Myelostat;NSC 141633;Omacetaxine mepesuccinate;Ephalotaxine, 4-methyl(2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester);
Molecular FormulaC29H39NO9
Molecular Weight545.62126
AppearanceOff-white Cryst
refractive index1.604
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Hazard T+: Very toxic;Xi: Irritant;
Risk R26/27/28
Safety
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Safety information of Homoharringtonine (CAS NO.26833-87-4):
Hazard Codes: .gif)
T+,.gif)
Xi
Risk Statements: 26/27/28-36/37/38
R26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 36/37/39-45-27-26
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S27: Take off immediately all contaminated clothing
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
RTECS: FK0260000
HazardClass: 6.1(a)
PackingGroup: II
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD10 |
intravenous |
640ug/kg (0.64mg/kg) |
BEHAVIORAL: FOOD INTAKE (ANIMAL)
CARDIAC: CHANGE IN RATE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
National Cancer Institute Report. Vol. AUG1982, |
| mouse |
LD50 |
intraperitoneal |
3170ug/kg (3.17mg/kg) |
? |
Chinese Medical Journal Vol. 92, Pg. 175, 1979. |
| mouse |
LD50 |
intravenous |
2400ug/kg (2.4mg/kg) |
? |
Journal of Ethnopharmacology. Vol. 24, Pg. 1, 1988. |
| mouse |
LD50 |
oral |
7456ug/kg (7.456mg/kg) |
? |
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| mouse |
LD50 |
subcutaneous |
3948ug/kg (3.948mg/kg) |
? |
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
