Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one,10-chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)- cas no:27060-91-9

NameOxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one,10-chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-
CAS27060-91-9
SynonymsOxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one,10-chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)- (8CI);Coreminal; Flutazolam; MS 4101; Ro 7-6102
Molecular FormulaC19H18 Cl F N2 O3
Molecular Weight376.84

refractive index1.672

Safety

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When Flutazolam (CAS NO.27060-91-9) is heated to decomposition ,it emits toxic fumes of F⁻, Cl⁻, and NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1680mg/kg (1680mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
mouse	LD50	oral	1910mg/kg (1910mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 2335, 1978.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat	LD50	intraperitoneal	4050mg/kg (4050mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat	LD50	oral	> 6gm/kg (6000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat	LD50	subcutaneous	> 6gm/kg (6000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.