2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, (2R)- cas no:27262-45-9

Name2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, (2R)-
CAS27262-45-9
Synonyms2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, (R)-; 2',6'-Pipecoloxylidide, 1-butyl-, (+)-(8CI); (+)-(R)-Bupivacaine; (+)-Bupivacaine; (R)-(+)-Bupivacaine;(R)-Bupivacaine; D-(+)-Bupivacaine; d-Bupivacaine
Molecular FormulaC18H28 N2 O
Molecular Weight288.48

refractive index1.547

Safety

Poison by subcutaneous, intratracheal and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x. See other bupicaine or bupivacaine entries.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	7900ug/kg (7.9mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.
mouse	LD50	subcutaneous	30mg/kg (30mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.
rabbit	LD50	intratracheal	10mg/kg (10mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976.
rabbit	LD50	parenteral	> 120mg/kg (120mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976.
rabbit	LDLo	intravenous	5500ug/kg (5.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.
rat	LD50	intravenous	3800ug/kg (3.8mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.
rat	LD50	subcutaneous	38mg/kg (38mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.