27314-97-2|3-amino-1,2,4-benzotriazine-1,4-dioxideProducts Supply

3-amino-1,2,4-benzotriazine-1,4-dioxide cas no:27314-97-2

Synonyms: tirapazamine

Identification

Name3-amino-1,2,4-benzotriazine-1,4-dioxide
CAS27314-97-2
Synonymstirapazamine
Molecular FormulaC7H6N4O2
Molecular Weight178.15

Chemical Properties

AppearanceOrange-red crystalline powder
refractive index1.777
storage temp2-8°C

Safety Data

Hazard Xi: Irritant;
Risk 36/37/38
Safety

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing
RTECS: DM0671500

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	89mg/kg (89mg/kg)		International Journal of Radiation Oncology, Biology, Physics. Vol. 16, Pg. 977, 1989. Link to PubMed
mouse	LD50	intravenous	101mg/kg (101mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	British Journal of Cancer, Supplement. Vol. 20, Pg. 84, 1993.
rat	LD	intravenous	> 36mg/kg (36mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" ENDOCRINE: OTHER CHANGES BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Toxicologist. Vol. 12, Pg. 154, 1992.
rat	LD50	intraperitoneal	59390ug/kg (59.39mg/kg)		Archives of Toxicology. Vol. 66, Pg. 100, 1992. Link to PubMed

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3-amino-1,2,4-benzotriazine-1,4-dioxide cas no:27314-97-2

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