1,2-Benzisothiazole,3-(2-propen-1-yloxy)-, 1,1-dioxide cas no:27605-76-1
Synonyms: 1,2-Benzisothiazole,3-(2-propenyloxy)-, 1,1-dioxide (9CI);1,2-Benzisothiazole, 3-(allyloxy)-,1,1-dioxide (8CI);3-Allyloxy-1,2-benzisothiazol-1,1-dioxide;3-Allyloxy-1,2-benzisothiazole 1,1-dioxide;3-Allyloxy-1,2-benzisothiazole-1,1-oxide;Oryzemate;PO 20;PO 20(pharmaceutical);Probenazole;
Name1,2-Benzisothiazole,3-(2-propen-1-yloxy)-, 1,1-dioxide
CAS27605-76-1
Synonyms1,2-Benzisothiazole,3-(2-propenyloxy)-, 1,1-dioxide (9CI);1,2-Benzisothiazole, 3-(allyloxy)-,1,1-dioxide (8CI);3-Allyloxy-1,2-benzisothiazol-1,1-dioxide;3-Allyloxy-1,2-benzisothiazole 1,1-dioxide;3-Allyloxy-1,2-benzisothiazole-1,1-oxide;Oryzemate;PO 20;PO 20(pharmaceutical);Probenazole;
Molecular FormulaC10H9NO3S
Molecular Weight223.25
refractive index1.604
storage temp0-6°C
Safety
Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx.
|
Organism
|
Test
Type
|
Route
|
Reported Dose (Normalized Dose)
|
Effect
|
Source
|
|
mouse
|
LD50
|
intraperitoneal
|
745mg/kg (745mg/kg)
|
Behavioral: somnolence (general depressed activity)
|
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 205, 1977.
|
|
mouse
|
LD50
|
oral
|
2750mg/kg (2750mg/kg)
|
Behavioral: altered sleep time (including change in righting reflex) behavioral: ataxia
|
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 205, 1977.
|
|
mouse
|
LD50
|
subcutaneous
|
> 5gm/kg (5000mg/kg)
|
|
Japan Pesticide Information. Vol. (37), Pg. 37, 1980.
|
|
rat
|
LD50
|
intraperitoneal
|
850mg/kg (850mg/kg)
|
|
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 219, 1977.
|
|
rat
|
LD50
|
oral
|
2030mg/kg (2030mg/kg)
|
|
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 7, Pg. 307, 1982.
|
|
rat
|
LD50
|
subcutaneous
|
> 5gm/kg (5000mg/kg)
|
|
Japan Pesticide Information. Vol. (37), Pg. 37, 1980.
|
