Levobunolol hydrochloride cas no:27912-14-7
Synonyms: (-)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalene-1(2H)-one hydrochloride;Vistagan;(-)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-3,4-dihydronaphthalene-1(2H)-one hydrochloride;Levobunolol.HCl;(2S)-N-(tert-butyl)-2-hydroxy-3-[(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]propan-1-aminium chloride;Betagan (TN);W 7000A;Gotensin;Prestwick_167;Levobunolol hydrochloride (JAN/USP);1(2H)-Naphthalenone,5-[(2S)-3-[(1,1- dimethylethyl)amino]-2-hydroxypropoxy]-3,4- dihydro-,hydrochloride;Levobunolol hydrochloride [USAN];1(2H)-Naphthalenone, 3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-, hydrochloride, (-)-;(-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochloride;1(2H)-Naphthalenone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-, hydrochloride, (-)-;Betagan;
NameLevobunolol hydrochloride
CAS27912-14-7
Synonyms(-)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalene-1(2H)-one hydrochloride;Vistagan;(-)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-3,4-dihydronaphthalene-1(2H)-one hydrochloride;Levobunolol.HCl;(2S)-N-(tert-butyl)-2-hydroxy-3-[(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]propan-1-aminium chloride;Betagan (TN);W 7000A;Gotensin;Prestwick_167;Levobunolol hydrochloride (JAN/USP);1(2H)-Naphthalenone,5-[(2S)-3-[(1,1- dimethylethyl)amino]-2-hydroxypropoxy]-3,4- dihydro-,hydrochloride;Levobunolol hydrochloride [USAN];1(2H)-Naphthalenone, 3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-, hydrochloride, (-)-;(-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochloride;1(2H)-Naphthalenone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-, hydrochloride, (-)-;Betagan;
EINECS(EC#)248-725-3
Molecular FormulaC17H25NO3.HCl
Molecular Weight327.85
Safety A poison by ingestion and intravenous routes. Questionable carcinogen with experimental neoplastigenic data reported. When heated to decomposition it emits toxic vapors of NOx and HCl.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QK4402500
- CHEMICAL NAME :
- 1(2H)-Naphthalenone,
3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-
, hydrochloride, (-)-
- CAS REGISTRY NUMBER :
- 27912-14-7
- LAST UPDATED :
- 199309
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C17-H25-N-O3.Cl-H
- MOLECULAR WEIGHT :
- 327.89
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year:
17,373,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year:
17,373,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1220 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New
York, Raven Press, 1980 Volume(issue)/page/year: -,317,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 78 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year:
17,373,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year:
17,373,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 435 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year:
17,373,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 131 gm/kg/2Y-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
18,353,1992
** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 112 gm/kg/80W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - uterine tumors
Tumorigenic - tumor types after systemic administration not seen
spontaneously
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
18,353,1992
