1′-(3-(10,11-DIHYDRO-3-CHLORO-5H-DIBENZ-(b,f)AZEPIN-5-YL)PROPYL)-(1,4′-BIPIPERID-INE)-4′-CARBOXAMIDE DIHYDROCHLORIDE cas no:28058-62-0

Name1′-(3-(10,11-DIHYDRO-3-CHLORO-5H-DIBENZ-(b,f)AZEPIN-5-YL)PROPYL)-(1,4′-BIPIPERID-INE)-4′-CARBOXAMIDE DIHYDROCHLORIDE
CAS28058-62-0
Synonyms1’-[3-(3-chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl][1,4’-bipiperidine]-4’-carboxamide dihydrochloride;CLOCAPRAMINEHCL;Clocapramine hydrochloride
EINECS(EC#)248-805-8
Molecular FormulaC₂₈H₃₇ClN₄O . 2ClH
Molecular Weight571.07

Safety

Poison by intraperitoneal route. Moderately toxic by ingestion. Mildly toxic by subcutaneous route. Experimental teratogenic and reproductive effects. A psychotropic drug. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	160mg/kg (160mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
mouse	LD50	oral	2550mg/kg (2550mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
mouse	LD50	subcutaneous	6500mg/kg (6500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
rat	LD50	intraperitoneal	125mg/kg (125mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
rat	LD50	oral	6800mg/kg (6800mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 391, 1971.
rat	LD50	subcutaneous	> 20gm/kg (20000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 193, 1973.