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Antimonate(2-), bis[m-[2,3-di(hydroxy-kO)butanedioato(4-)-kO1:kO4]]di-, potassium, hydrate (1:2:3), stereoisomer cas no:28300-74-5

Synonyms: Antimonate(2-),bis[m-[2,3-di(hydroxy-kO)butanedioato(4-)-kO1:kO4]]di-, dipotassium, trihydrate, stereoisomer (9CI);Antimonate(2-), bis[m-tartrato(4-)]di-, dipotassium, trihydrate (8CI);Antimonate(1-),aqua[tartrato(4-)]-, potassium, sesquihydrate, dimer;Antimony potassium tartrate;Antimonyl potassium tartrate, sesquihydrate;Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, antimony potassium salt;Potassium antimony tartrate;Tartaremetic;Tartox;

Identification
NameAntimonate(2-), bis[m-[2,3-di(hydroxy-kO)butanedioato(4-)-kO1:kO4]]di-, potassium, hydrate (1:2:3), stereoisomer
CAS28300-74-5
SynonymsAntimonate(2-),bis[m-[2,3-di(hydroxy-kO)butanedioato(4-)-kO1:kO4]]di-, dipotassium, trihydrate, stereoisomer (9CI);Antimonate(2-), bis[m-tartrato(4-)]di-, dipotassium, trihydrate (8CI);Antimonate(1-),aqua[tartrato(4-)]-, potassium, sesquihydrate, dimer;Antimony potassium tartrate;Antimonyl potassium tartrate, sesquihydrate;Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, antimony potassium salt;Potassium antimony tartrate;Tartaremetic;Tartox;
EINECS(EC#)234-293-3
Molecular FormulaC8H4K2O12Sb2.3(H2O)
Molecular Weight667.86
Chemical Properties
AppearanceTransparent crystals (effloresce on exposure to air) or Powder
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard Xn:Harmful;N:Dangerousfortheenvironment;
Risk R20/22;R51/53
Safety

Human poison by intravenous route, producing liver and kidney changes, somnolence, dyspnea, and pupillary dilation. Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Large doses cause severe liver damage. Human mutation data reported. Used medicinally, the therapeutic dose is close to the toxic dose. Upon decomposition it emits toxic fumes of K2O and Sb.
Hazard Codes: HarmfulXn,DangerousN
Risk Statements: 20/22-51/53 
R20/22:Harmful by inhalation and if swallowed. 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 61 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 15mg/kg (15mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
guinea pig LDLo intramuscular 55mg/kg (55mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
human LDLo oral 2mg/kg (2mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1097, 1966.
human TDLo intravenous 1392ug/kg (1.392mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Lancet. Vol. 210, Pg. 227, 1926.
man LD50 intravenous 249mg/kg/9D-I (249mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Tropical Medicine and Hygiene. Vol. 21, Pg. 38, 1918.
man LDLo intravenous 12mg/kg/1W-I (12mg/kg) LIVER: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Lancet. Vol. 210, Pg. 227, 1926.
mouse LD50 intraperitoneal 33mg/kg (33mg/kg)   Bulletin of the World Health Organization. Vol. 53, Pg. 379, 1976.
mouse LD50 intravenous 45mg/kg (45mg/kg)   Fortschritte der Arzneimittelforschung. Progress in Drug Research. Vol. 17, Pg. 108, 1973.
mouse LD50 subcutaneous 55mg/kg (55mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Proceedings of the Society for Experimental Biology and Medicine. Vol. 129, Pg. 284, 1968.
mouse LDLo oral 600mg/kg (600mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rabbit LD50 intravenous 12mg/kg (12mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 196, 1947.
rabbit LD50 oral 115mg/kg (115mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rat LD50 intraperitoneal 11mg/kg (11mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rat LD50 oral 115mg/kg (115mg/kg)   Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 24, 1966.
rat LDLo intramuscular 33mg/kg (33mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
 

 Potassium antimonyl tartrate sesquihydrate (CAS NO.28300-74-5) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.

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