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Glipizide cas no:29094-61-9

Synonyms: Glucotrol;Glydiazinamide;Prestwick_242;N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-pyrazine-2-carboxamide;Pyrazinecarboxamide,N-[2-[4-[[[(cyclohexylamino) carbonyl]amino]sulfonyl]phenyl]- ethyl]-5-methyl-;TK 1320;Glucotrol (TN);(Glipizide);

Identification
NameGlipizide
CAS29094-61-9
SynonymsGlucotrol;Glydiazinamide;Prestwick_242;N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-pyrazine-2-carboxamide;Pyrazinecarboxamide,N-[2-[4-[[[(cyclohexylamino) carbonyl]amino]sulfonyl]phenyl]- ethyl]-5-methyl-;TK 1320;Glucotrol (TN);(Glipizide);
EINECS(EC#)249-427-6
Molecular FormulaC21H27N5O4S
Molecular Weight445.53
Chemical Properties
AppearanceWhite or off-white crystalline powder
refractive index1.597
storage tempStore in a tightly closed container. Store in a dry area. Store at around 20 C.
Safety Data

Hazard Xi: Irritant;Xn: Harmful;
Risk R21
Safety

Safety Information of? Glipizide (CAS NO.29094-61-9):
Hazard Codes:?HarmfulXn,IrritantXi
Risk Statements: 21-36/38-46-62-63
21:Harmful in contact with skin
36/38:Irritating to eyes and skin?
46:May cause heritable genetic damage
62:Possible risk of impaired fertility?
63:Possible risk of harm to the unborn child?
Safety Statements: 24/25-53-36/37-26-25
24/25:Avoid contact with skin and eyes
53:Avoid exposure - obtain special instruction before use
36/37:Wear suitable protective clothing and gloves
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
25:Avoid contact with eyes????
WGK Germany: 3
RTECS: YS7640000
F: 10


Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS7640000
CHEMICAL NAME :
Urea, 1-cyclohexyl-3-((p-(2-(5-methylpyrazinecarboxamido)et hyl)phenyl)sulfonyl)-
CAS REGISTRY NUMBER :
29094-61-9
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C21-H27-N5-O4-S
MOLECULAR WEIGHT :
445.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,208,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,208,1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,208,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,208,1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,208,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,208,1971

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