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Home > products > Benzeneacetamide,4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-

Benzeneacetamide,4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]- cas no:29122-68-7

Synonyms: Acetamide,2-[p-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]- (8CI);(RS)-Atenolol;Alinor;Altol;Anselol;Antipressan;Apo-Atenolol;AteHexal;Atecard;Atelol;Atenblock;Atendol;Atenet;Ateni;Ateno;Atenolol;Aterol;B-Vasc;Betacard;Tenormin;Tenormine;Tensimin;Tredol;Urosin;Vericordin;Xaten;1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol;Catenol;Catenolol;Corotenol;Farnormin;Hipres;ICI 66082;Internolol;Lo-ten;Lotenal;Normalol;Noten;Oraday;Prenormine;SelesBeta;Serten;Telol;Teno-basan;Tenolin;Tenoprin;

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Identification
NameBenzeneacetamide,4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
CAS29122-68-7
SynonymsAcetamide,2-[p-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]- (8CI);(RS)-Atenolol;Alinor;Altol;Anselol;Antipressan;Apo-Atenolol;AteHexal;Atecard;Atelol;Atenblock;Atendol;Atenet;Ateni;Ateno;Atenolol;Aterol;B-Vasc;Betacard;Tenormin;Tenormine;Tensimin;Tredol;Urosin;Vericordin;Xaten;1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol;Catenol;Catenolol;Corotenol;Farnormin;Hipres;ICI 66082;Internolol;Lo-ten;Lotenal;Normalol;Noten;Oraday;Prenormine;SelesBeta;Serten;Telol;Teno-basan;Tenolin;Tenoprin;
EINECS(EC#)249-451-7
Molecular FormulaC14H22N2O3
Molecular Weight266.34
Chemical Properties
AppearanceWhite to off-white crystalline powder
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety Data

Hazard UN NO.
Risk R22
Safety

Safety Information of?Atenolol (CAS NO.29122-68-7):
Hazard Codes: Xn
Risk Statements: 22-36/37/38-20/21/22
22: Harmful if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 22-24/25-36-26
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
36: Wear suitable protective clothing
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany: 2
RTECS: AC3600000


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 10204ug/kg (10.204mg/kg) BEHAVIORAL: COMA

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Anesthesiology. Vol. 83, Pg. 204, 1995.
man TDLo oral 49mg/kg/30D-I (49mg/kg) BEHAVIORAL: EXCITEMENT Journal of Clinical Pyschopharmacology. Vol. 6, Pg. 390, 1986.
man TDLo oral 86mg/kg/60D-I (86mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" American Journal of Medicine. Vol. 85, Pg. 586, 1988.
man TDLo oral 129mg/kg/26W- (129mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: COUGH

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Annales de Medecine Interne. Vol. 148, Pg. 505, 1997.
mouse LD50 intraperitoneal 134mg/kg (134mg/kg) ? Toksikologicheskii Vestnik. Vol. (4), Pg. 33, 1995.
mouse LD50 intravenous 57mg/kg (57mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
mouse LD50 oral 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
mouse LD50 subcutaneous > 400mg/kg (400mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
rabbit LD50 intravenous 50mg/kg (50mg/kg) ? Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 17, Pg. 425, 1979.
rat LD50 intravenous 77mg/kg (77mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
rat LD50 oral > 2gm/kg (2000mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
rat LD50 subcutaneous > 600mg/kg (600mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
women TDLo oral 16mg/kg (16mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION Annals of Emergency Medicine. Vol. 14, Pg. 161, 1985.
women TDLo oral 42mg/kg/3W-I (42mg/kg) ? British Medical Journal. Vol. 294, Pg. 1324, 1987.
women TDLo oral 1080mg/kg/78W (1080mg/kg) BLOOD: LEUKOPENIA

MUSCULOSKELETAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Journal of Rheumatology. Vol. 13, Pg. 446, 1986.

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